高血压病患者脑腔隙性病变危险因素分析

Risk Factors of Lacunar Infarction in Hypertensive Patients

目的 :分析高血压病患者合并腔隙性脑梗塞的危险因素。方法 :观察 75例住院的高血压病患者 ,以头颅磁共振扫描有无腔隙性脑梗塞分成二组 ,并进行血脂、血黏度、血小板聚集率、血尿酸、尿微量白蛋白、纤溶、糖耐量试验及动态血压检查。并进行组间比较及 L ogistic回归统计分析。结果 :高血压病合并腔梗组高密度脂蛋白、微量白蛋白尿、PAI- 1、平均收缩压、最大收缩压、糖负荷后最大胰岛素及胰岛素释放曲线下面积与非腔梗组有显著差异。结论 :除高血压因素外 ,高密度脂蛋白降低 ,微量白蛋白尿 ,PAI-

Aim:To analysis the risk factors of lacunar stroke in essential hypertensive patients. Methods:Seventy five patients with EH were classified into two groups based on with lacunar infarction( n =48) and without lacunar infarction( n =27) by MRI test. Oral glucose tolerance tests,lipid analyses,platelet aggregation,blood viscosity,uric acid,microalbuminuria,tPA,PAI 1 and 24 hours ABPM were studied. Logistic regression analyses was used to find the independent risk factors of lacunar infarction. Results:High density lipoprotein were significantly decreased in the lacunar infarction compared with the group without. Microalbuminuria,PAI 1,the mean systolic blood pressure and the maximum systolic blood pressure levels were significantly higher in the lacunar infarction group .In the lacunar infarction group,the maximum insulin and 3 hour insulin area(area under the plasma insulin concentration curve) during a 75 g oral glouse tolerance test were significantly increased.Logistic regression analysiss showed microalbuminuria and PAI 1 may be independent risk factors of lacunar infarction. Conclusions:Beside the hypertension,the HDL c,microalbumin uria,insulin curve under area,and PAI 1 may be contribute the risk factors in lacunar infarction of hypertension patients.