摘要
报道了一种以2-氯-5-溴苯甲酸为底物经酰化,还原,甲酰化等多步反应得到4-氯-3-(4-乙氧基苄基)苯甲醛的简便合成,提供了一种SGLT-2抑制剂Ertugliflozin关键中间体的新合成方法,该方法所用原料和试剂廉价易得,合成路线简洁,操作简便,收率高,有利降低生产成本,提高生产效率。
A facile synthesis of 4 - chloro - 3 - （4 - Bbenzyl） benzaldehyde was reported. The synthesis was performed by the acylation, reduction and hydroformylation of 2 - chloro -5 -bromo -benzoic acid. This procedure offered easy access to obtain key intermediates of Ertugliflozin in an accessible materials and facile conditions with good yields, even to reduce costs and improve production efficiency.
出处
《化工时刊》
CAS
2013年第4期21-24,共4页
Chemical Industry Times
