人参注射液治疗慢性心力衰竭的Meta分析

Meta-analysis of Ginseng Injection for Treatment of Chronic Heart Failure

目的系统评价西医常规治疗加人参注射液与单纯西医常规治疗比较治疗慢性心力衰竭(CHF)的临床疗效及安全性。方法计算机检索PubMed、Medline、中国生物医学文献数据库、中国期刊全文数据库、中文科技期刊数据库、万方数据全文等数据库。对搜集到的临床随机对照试验进行方法学质量评估,并采用RevMan5.1.7软件进行Meta分析。结果共纳入6个研究,合计452例患者。Meta分析结果显示,在西医常规抗CHF药物治疗基础上加用人参注射液较单纯抗CHF西药治疗效果好[RR=1.22,95%CI(1.12,1.34),P<0.000 01];人参注射液可在治疗CHF的同时,纠正CHF患者的甲状腺激素异常,改善血液流变学指标,控制血小板聚集等。结论西医常规治疗加人参注射液较单纯西医常规治疗CHF可进一步提高临床疗效,但由于纳入研究质量较低,尚需要大量高质量研究加以验证。

Objective To evaluate the clinical efficacy and safety of rountine western medicine combined with ginseng injection and western medicine only on the patients with chronic heart failure（CHF）.Methods Randomized controlled trials（RCTs） on ginseng injection in treatment of CHF were searched in PubMed, Medline,CBMDISC,CNKI,VIP and Wanfang database.Quality of them was evaluated strictly and statistical analysis was performed with Cochrane Collaboration＇s RevMan5.1.7 software.Results Six trials involving 452 patients were included.The results of meta-analysis showed that the combination of western medicine and ginseng injection significantly improved the clinical comprehensive effect [RR=1.22,95%CI（1.12,1.34）,P 0.000 01].Meanwhile,ginseng injection might correct the abnormal of thyroid hormone in patients with CHF,and improve blood rheology such as control platelet aggregation.Conclusion The therapeutic effect of western medicine combined with ginseng injection therapy on CHF patients is better than that of simple western medicine treatment.However,high-quality and large-scaled trials are required for verification because of the poor quality of current studies.