人参皂苷Rg3微乳的质量评价

Quality Evaluation of Ginsenoside Rg3 Microemulsion

目的对自制人参皂苷Rg3微乳剂的质量进行评价。方法通过测定人参皂苷Rg3的理化参数、载药量及体外释放度对人参皂苷Rg3微乳剂进行质量评价。结果所制备的人参皂苷Rg3微乳剂为无色澄清、透明均一的溶液,平均载药量为3.5 mg/mL,体外释放度试验表明Rg3微乳的释药速度和程度都明显大于市售胶囊。结论制备的人参皂苷Rg3微乳剂的理化参数及体外释放度等指标达到药典要求。

Objective To evaluate the quality of self-made Ginsenoside Rg3 microemulsion.Methods The quality evaluation of Ginsenoside Rg3 microemulsion was evaluated with determination of ginsenoside Rg3 physico-chemical parameters,drug loading and in vitro release.Results Ginsenoside Rg3 microemulsion is colorless and transparent.The average drug loadings is 3.5 mg/mL.The test of Rg3 in vitro release index showed that the ginsenoside Rg3 microemulsion is better than those capsule in market at releasing speed and the degree.Conclusion The indexes of Ginsenoside Rg3 microemulsion such as physico-chemical parameters and in vitro release meet the requirement of pharmalopoeia.