期刊文献+

维生素D对胰岛功能的调控作用 被引量:11

Regulation of Vitamin D on Islets Function
下载PDF
导出
摘要 近年来研究发现,维生素D与2型糖尿病之间存在密不可分的关系。维生素D可通过抑制胰岛β细胞凋亡,促进胰岛β细胞分泌和削弱胰岛α细胞分泌来调控胰岛功能。本文通过阐述维生素D及维生素D受体基因多态性与2型糖尿病的关系,探讨维生素D对胰岛功能调控的作用机制。 Recent studies have found that there is a close relationship between Vitamin D and type 2 diabetes. Vitamin D regulates islets function by inhibiting pancreatic β - cell apoptosis and promoting islet β - cell secretion and weakening the islet alpha cells secretion. This article will expound the relationship between Vitamin D and Vitamin D receptor gene polymorphisms with type 2 diabetes in order to explore the mechanism of Vitamin D on the regulation of islet function.
出处 《中国全科医学》 CAS CSCD 北大核心 2013年第12期1404-1407,共4页 Chinese General Practice
基金 国家自然科学基金项目(30900697) 江苏省医学重点人才项目(RC2011138)
关键词 维生素D 糖尿病 2型 受体 骨化三醇 多态性 单核苷酸 胰岛功能 Vitamin D Diabetes mellitus, type 2 Receptors, calcitriol Polymorphism, single nucleotide Islets function
  • 相关文献

参考文献46

  • 1Yang WY, Lu JM, Weng JP, et al. Prevalence of diabetes among men and women in China [J]. N Engl J Med, 2010, 362 (12) : 1090 - 1101.
  • 2Souberbielle JC, Body JJ, Lappe JM, et al. Vitamin D and musculo- skeletal health, cardiovascular disease, autoimmunity and cancer: rec- ommendations for clinical practice [J]. Autoimmun Rev, 2010, 9 (11) : 709 -715.
  • 3Mithal A, Wahl DA, Bonjour JP, et al. Global vitamin D status and determinants of hyp0vitaminosis D [ J ]. Osteopoms Int, 2009, 20 (11): 1807 -1820.
  • 4Hutchinson MS, Figenschau Y, Alms B, et al. Serum 25 - hydroxyvitamin D levels in subjects with reduced glucose tolerance and type 2 diabetes - the Tromsg OGTY - study [ J ]. Int J Vitam Nutr Res, 2011, 81 (5): 317-327.
  • 5Hurskainen AR, Virtanen JK, Tuomainen TP, et al. Association of serum 25 - hydroxyvitamin D with type 2 diabetes and markers of insulin resistance in a general older population in Finland [ J]. Diabetes Metab Res Rev, 2012, 10 (8): 2280-2286.
  • 6Molem IG, Martfnez GR, Morcillo S, et al. Vitamin D and incidence of diabetes: a prospective cohort study [J]. Clin Nutr, 2011, 26 (12) : 867 -870.
  • 7Pinelli RN, Jaber LA, Brown MB, et al. Serum 25 - hydroxy vitamin D and insulin resistance, metabolic syndrome, and glucose intolerance among Arab Americans [J]. Diabetes Care, 33 (6) : 1373 -1375.
  • 8Jarvandi S, Joseph L, Gougeon R, et al. Vitamin supplementation and blood pressure in type 2 diabetes [J]. Diabet Med, 2012, 13 (3) : 1464 - 5491.
  • 9Plumand LA, Zella JB. Vitamin D compounds and diabetic nephropathy [J]. Arch Biochem Biophys, 2012, 18 (3) : 957 -970.
  • 10Payne JF, Ray R, Watson DG, et al. Vitamin D insufficiency in dia- betic retinopathy [J]. Endocr Pract, 2011, 22 (9) : 1 - 18.

二级参考文献39

  • 1李慧敏,缪珩,鲁一兵,耿厚法,蒋秀琴.维生素D受体基因多态性与2型糖尿病易感性的研究[J].中国现代医学杂志,2005,15(7):989-992. 被引量:21
  • 2张红红,陶国枢,高宇红,刘建伟,吴青,牟小芬,胡亚卓,陈瑞英,冷兴文.我国四种民族维生素D受体基因多态性分布的研究[J].中国骨质疏松杂志,2006,12(1):1-3. 被引量:24
  • 3邵加庆,岩下乃夕,杜宏,王燕燕,赵明,绵田裕孝,河盛隆造,王坚.坎地沙坦对db/db糖尿病小鼠胰岛功能和结构的保护[J].中华内分泌代谢杂志,2007,23(2):110-116. 被引量:9
  • 4徐家蓉,鲁一兵,耿厚法,吴珺,缪珩.维生素D受体基因多态性与2型糖尿病发病的关联[J].中国组织工程研究与临床康复,2007,11(30):5881-5883. 被引量:21
  • 5Norman AW. The Vitamin D endocrine System : identification of Another Piece of the Puzzle [ J ]. Endocrinology, 1994,134(4) :1601A - 1601C.
  • 6Lee S, Clark SA, Gill RK, et al. 1,25 - Dihydroxyvitamin D3 and Pancreatic Beta - cell Function:vitamin D Receptors, Gene Expression, and Insulin Secretion [ J ]. Endocrinology,1994,134(4) :1 602 - 1 610.
  • 7Ogunkolade BW, Boucher B J, Prahl JM, et al. Vitamin D receptor(VDR)mRNA and VDR Protein Levels in Relation to Vitamin D Status, Insulin Secretory Capacity, and VDR Genotype in Bangladeshi Asians [ J ]. Diabetes, 2002,51 (7) :2294 - 300.
  • 8Malecki MT, Frey J, Moczulski D, et al. Vitamin D Receptor Polymorphism and Association with Type 2 Diabetes Mellitus in a Polish Population [ J ]. Exp Clin Endocrinol Diabetes ,2003,111 ( 8 ) :505 - 509.
  • 9Guo SW, Magnuson VL, Schiller JJ, et al. Meta - analysis of Vitamin D Receptor Polymorphisms and Type 1 Diabetes:a HuGE review of Genetic Association Studies [ J ]. Am J Epidemiol,2006,164(8) :711 -724.
  • 10Uitterlinden AG, Fang Y, Van Meurs JB, et al. Genetics and Biology of Vitamin D Receptor Polymorphisms [ J ]. Gene,2004,338(2) :143 - 156.

共引文献40

同被引文献89

  • 1杨华,袁茹茹,夏章勇,苗滢,马秀清,赵芬,崔可密.皮质下动脉硬化性脑病患者血浆抵抗素、瘦素水平及其相关性研究[J].疑难病杂志,2006,5(5):337-339. 被引量:3
  • 2李发明.维生素D免疫调节作用对儿童哮喘的影响[J].实用心脑肺血管病杂志,2013,21(7):123.
  • 3PREOBRAZHENSKAYA I S.Dementia:epidemiology,clinical picture,diagnosis,approaches to therapy[J].Neurology,neuropsychiatry,Psychosomatics,2013(4):71-77.
  • 4GILANI S,ADIL M,ULUDUZ D,et al.Vitamin D Deficiency and Osteoporosis in Stroke Survivors:An Analysis of National Health and Nutritional Examination Survey(NHANES)2001-2006(P04.080)[C]//Neurology.530 WALNUT ST,PHILADELPHIA,PA 19106-3621 USA:LIPPINCOTT WILLIAMS&WILKINS,2013,80.
  • 5NG L L,SANDHU J K,SQUIRE I B,et al.Vitamin D and prognosis in acute myocardial infarction[J].International journal of cardiology,2013,168(3):2341-2346.
  • 6李大年.现代神经內科学[M].山东:山东科学技术出版社,2002.
  • 7LUTSEY P L,MICHOS E D.VITAMIN D,CALCIUM,and atherosclerotic risk:evidence from serum levels and supplementation studies[J].Current atherosclerosis reports,2013,15(1):293.
  • 8Whiting DR,Guariguata L,Weil C,et al.IDF diabetes ailas:global estimates of the prevalence of diabetes for 2011and2030[J].Diab Res Clin Pract,2011,94:311-321.
  • 9Mancia G,Laurent S,Agabiti-Rosei E,et al.Reappraisal of European guidelines on hypertension management:a European Society of Hypertension Task Force document[J].Blood Pressure,2009,18(6):308-347.
  • 10Hossein-Nezhad A,Holick MF.Vitamin D for health:aglobal perspective[J].Mayo Clin Proc,2013,88(7):720-755.

引证文献11

二级引证文献61

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部