急性脊髓损伤后血清中ALT和AST活性变化的临床初步观察

The determination of ALT and AST of patients with acute spinal cord injury

目的 :探讨血清中谷丙转氨酶 (ALT)和谷草转氨酶 (AST)的活性与急性脊柱脊髓损伤的关系 ,并评价ALT和AST活性的变化与脊髓损伤严重程度的关系。方法 :测定 136例急性脊柱脊髓损伤患者在急性期及恢复期血清中ALT和AST的水平 ,以及 30例急性脊柱骨折患者血清中ALT和AST的浓度 ,分别进行统计学处理分析。结果 :急性脊柱脊髓损伤患者血清中ALT和AST活性显著高于其恢复期及单纯脊柱骨折患者 ,并且在急性期脊髓完全损伤患者血清中ALT和AST活性明显高于脊髓不完全损伤患者。结论 :ALT和AST水平改变与脊髓损伤及其严重程度可能有一定关系。

Objective:In order to evaluate the relationship between the activity of ALT and AST and the degree of spinal cord injury,we analyzed the activity of ALT and AST in serum of the patients with acute spinal cord injury(ASCI),the patients with fracture of spine and the ASCI patients at the recovery stage Methods:We investigated the ALT and AST activity in serum of 136 SCI patients in acute and recovery stages respectively by auto Olympus 600 biochemistry analysis instrument Results:The activity of ALT and AST of ASCI patients is much higher than that at recovery phase,and it is also higher than that of patients with spinal column fracture,while activity of patients with complete spinal cord injury is higher than that of patients suffered from incomplete spinal cord injury Conclusion:The activity of AST and ALT in serum may be related to spinal cord injury and its degree