苯并吡喃酯类化合物的合成及其生物活性

Synthesis and Bioactivity of Esters of Benzopyran

为寻找活性更高、降压作用更理想的钾通道开放剂 ,合成了 10个苯并吡喃酯类衍生物及3个中间体 ,并对它们进行了体外低钾诱导的血管收缩抑制试验 .结果表明 :化合物浓度为 1×10 -4 mol/L时对低钾 (2 0mmol/L)引起的血管收缩有不同程度的抑制作用 ,化合物 (Ⅰ )和 (Ⅱa)的活性较好 ,抑制率分别为 86 .4%和 79.3 %

In order to search for new novel antihypertensives,considerable attention was given to the potassium channel openers of benzopyrans.10 esters of benzopyrans were designed and synthesized.The biological activities of the compounds were evaluated.At the dose of 1×10 -4 mol·L -1 ,(Ⅰ) and (Ⅱa) could inhibit the low potassium induced vessel contraction by 86 4% and 79 3% respectively.