8-氮杂螺〔4,5〕癸烷-7,9-二酮的合成路线改进

Modification of the Synthesis of 8-Azaspiro〔4,5〕decane-7,9-dione

在总结文献方法的基础上 ,设计出一种新的合成方法 :利用环戊烷 1,1 二乙酸与碳酸铵反应合成抗焦虑药———丁螺环酮的中间体 8 氮杂螺〔4,5〕癸烷 7,9 二酮 ,本方法收率高 ,工艺简单 。

As an intermediate of buspirone,8 azaspiro〔4,5〕decane 7,9 dione was synthesized by a one step reaction.This method has never been reported.The yield was 80%.The process may be easily used in industry.