匹维溴铵治疗腹泻型肠易激综合征的临床观察

The Effect of Pinaverium Bromid on the Patients with Diarrhea Predominant Irritable Bowel Syndrome

目的观察匹维溴铵对腹泻型肠易综合征(IBS)的治疗效果。方法 95例腹泻型肠易激综合征患者接受匹维溴铵治疗2周,观察患者治疗前后腹痛、腹胀、腹泻、大便形态、生活质量改善以及药物副反应。结果接受匹维溴铵治疗2周后,腹泻型lBS患者腹痛、腹胀和腹泻症状评分均较治疗前显著降低(P<0.05),大便性状评分较治疗前下降(P<0.05),生活质量评分较治疗前提高(P<0.05)。但在停药结束后4周上述指标评分较治疗前无明显差异(P>0.05)。结论匹维溴铵可有效缓解腹泻型lBS患者的临床症状,但治疗疗程值得进一步研究。

Objective To investigate the effect of pinaverium bromide on the patients with diarrhea predominant irritable bowel syndrome. Methods 95 patients with diarrhea predominant irritable bowel syndrome were treated with pinaverium bro- mide for two weeks. The abdominal pain, abdominal distension, diarrhea, stool form, quality of life and adverse effect were recor- ded before and after the treatment. Results The score of abdominal pain, abdominal distension and diarrhea of the patients af- ter treatment were obviously lower comparing with prior treatment （ P 〈 0.05 ）. The score of bowel form was also lower compa- ring with prior treatment （ P 〈 0.05 ）. The score of quality of life of the patients after treatment were significantly higher than that of prior treatment （ P 〈 0.05 ）. However, there were no obviously difference between these investigation targets before treat- ment and after stopping treatment for 4 weeks （ P 〉 0.05 ）. Conclusion Pinaverium bromide can obviously relieve the symp- toms of diarrhea predominant irritable bowel syndrome,however,the course of treatment need further investigation.