577例大肠癌相关危险因素的研究

The Study on the Colorectal Cancer Related Risk Factors of 577 Cases

目的探讨惠州地区大肠癌发病的相关危险因素。方法对惠州地区577例大肠癌患者进行大肠癌危险因素单因素条件Logistics回归分析,纳入多因素条件Logislic回归模型进行多因素分析,计算各危险因素与大肠癌的关联程度OR值及其95%可信区间。结果对577例大肠癌患者进行单因素条件Logistics回归分析发现,糖尿病病史、既往有大肠腺瘤性息肉病史和一级亲属患大肠腺瘤或大肠癌家族史和大肠癌的发生有关(P<0.05)。根据单因素的分析结果,将有意义的变量引入到多因素条件Logistic回归模型进行分析,结果显示糖尿病病史、既往大肠腺瘤性息肉病史、一级亲属患大肠腺瘤或大肠癌家族史是大肠癌发生的危险因素(P均<0.05,OR值均>1)。结论糖尿病病史、既往有大肠腺瘤性息肉病史和一级亲属患大肠腺瘤性息肉或大肠癌家族史增加了患大肠癌的危险性。

Objective To study the risk factorts for colorectal cancer in Huizhou district. Methods Univariate analysis of logistic regression was used for risk factors in 577 eolorectal cancer people in Huizhou district, then the data was brought into muhivariate analysis of logistic regression model, calculate the risk factors associated with the extent of colorectal cancer （ OR value） , and the 95 % confidence interval. Results The discovery of 577 patients with coloreetal cancer of univariate analysis of logistic regression ： the incidence of colorectal cancer were related to the diabetes, previous history of colorectal adenomatous pol- yps and first-degree relative with colorectal adenoma or colorectal cancer（ P 〈 0.05 ）. Then the data was brought into multivari- ate analysis of Logistic regression model and show that the incidence of colorectal cancer were related to diabetes, previous his- tc,ry of colorectal adenomatous polyps and first-degree relatives with colorectal adenoma or colorectal cancer （P 〈 0.05, OR 〉 1）. Conclusion The retrospective case-control study showed that diabetes, previous history of colorectal adenomatous polyps and first-degree relative with colorectal adenoma or colorectal cancer increased the risk of colorectal cancer.