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IL-9和IL-10基因拷贝数变异与白癜风发病的相关性 被引量：2

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摘要 目的:分析白细胞介素-9(IL-9)和白细胞介素-10(IL-10)基因拷贝数变异与白癜风发病的相关性。方法:采用荧光定量聚合酶链反应(PCR)对319例白癜风患者和424例健康者的IL-9和IL-10基因拷贝数变异进行研究。结果:白癜风患者的IL-9和IL-10基因拷贝数与健康人的IL-9和IL-10基因拷贝数有显著差异(P<0.05),白癜风患者中这两个基因的拷贝数较健康人明显增高。结论:IL-9和IL-10基因拷贝数变异与白癜风发病有明显的相关性。IL-9和IL-10基因拷贝数增加可能会增加白癜风的易感性。
作者 唐莉华 钟绮丽 张杰 陈办成 邵勇 胡小平 于波
机构地区 安徽医科大学附属北京大学深圳医院皮肤科 安徽医科大学 北京大学深圳医院
出处 《中国麻风皮肤病杂志》 2013年第4期248-250,共3页 China Journal of Leprosy and Skin Diseases
关键词 IL-9 IL-10 拷贝数变异 白癜风
分类号 R758.41 [医药卫生—皮肤病学与性病学]
  • 相关文献

参考文献15

  • 1张莹,刘玲,李凯,李春英,杨励,孙林潮,高天文.中国汉族NOS2基因多态性与白癜风发病相关性研究[J].中国美容医学,2008,17(8):1173-1175. 被引量：1
  • 2Le Poole IC, Das PK, van den Wiji^aard RM, et al. Review of theetiopathomechanism of vitiligo: a convergence theory. Exp Derma-tol, 1993,2(4) : 145 - 153.
  • 3Ortonne JP, Bose SK. Vitiligo: where do we stand? Pigment CellRes, 1993,6(2) :61-72.
  • 4Le Poole C, Boissy RE. Vitiligo. Semin Cutan Med Suig, 1997,16(1):3-14.
  • 5Spritz RA. Hie genetics of generalized vitiligo. Curr Dir Autoim-mun,2008,10:244 - 257.
  • 6Veldhoen M, Uyttenhove C,van Snick J, et al. Transforminggrowth factor - beta * reprograms ’ the differentiation of T helper 2cells and promotes an interleukin 9 - producing subset. Nat Immu-nol,2008,9( 12):1341 - 1346.
  • 7Dardalhon V,Awasthi A, Kwon H, et al. IL- 4 inhibits TGF- be-ta -induced Foxp3 + T cells and, together with TGF - beta, gener-ates IL-9+ IL - 10+ Foxp3( - ) effector T cells? Nat Immunol,2008,9(12):1347-1355.
  • 8田洁,王胜军,许化溪.Th9细胞:一种新型效应性CD4^+ T细胞亚群[J].细胞与分子免疫学杂志,2009,25(9):853-855. 被引量：30
  • 9McKinney C, Merriman ME, Chapman PT, et al. Evidence for aninfluence of chemokine ligand 3 - like 1 (CCL3L1) gene copy num-ber on susceptibility to liieumatoid arthritis. Ann Rheum Dis,2008,67(3):409-413.
  • 10Rovelet - Lecrux A, Harmequin D, Raux G, et al. APP locus du-plication causes autosomal dominant early - onset Alzheimer diseasewith cerebral amyloid angiopathy. Nat Genet, 2006,38(1) : 24 -26.

二级参考文献18

  • 1Harrington LE,Hatton RD,Mangan PR,et al.Interleukin17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages[J].Nat Immunol,2005,6(11):1123-1132.
  • 2Soussi-Gounni A,Kontolemos M,Hamid Q,et al.Role of IL-9 in the pathophysiology of allergic diseases[J].J Allergy Clin Immunol,2001,107(4):575-582.
  • 3Veldhoen M,Uyttenhove C,Snick VJ,et al.Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset[J].Nat immunol,2008,9(12):1341-1346.
  • 4Dardalhon V,Awasthi A,Kwon H,et al.IL-4 inhibits TGF-beta-induced Foxp3^+ T cells and,together with TGF-beta,generates IL-9^+ IL-10^+ Foxp3(-) effector T cells[J].Nat Immunol,2008,9(12):1347-1355.
  • 5Renauld JC,Goethals A,Houssiau F,et al.Human P40/IL-9 expression in activated CD4+ T cells,genomic organization,and comparison with the mouse gene[J].J Immunol,1990,144(11):4235-4241.
  • 6Nicolaides NC,Holroyd KJ,Ewart SL,et al.Interleukin-9:A candidate gene for asthma[J].Proc Natl Acad Sci USA,1997,94(24):13175-13180.
  • 7Kermouni A,Van Roost E,Arden KC,et al.The IL-9 receptor gene(IL-9R):genomic structure,chromosomal localization in the pseudoautosomal region of the long arm of the sex chromosomes,and identification of IL-9R pseudogenes at 9qter,10pter,16pter,and 18pter[J].Genomics,1995,29(2):371-382.
  • 8Vermeesch JR,Petit P,Kermouni A,et al.The IL-9 receptor gene,located in the Xq/Yq pseudoautosomal region,has an autosomal origin,escapes X inactivation and is expressed from the Y[J].Hum Mol Genet,1997,6(1):1-8.
  • 9Demoulin JB,Uyttenhove C,Van Roost E,et al.A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation,antiapoptotic activity,and growth regulation by IL-9[J].Mol Cell Biol,1996,16(9):4710-4716.
  • 10Soussi Gounni A,Gregory B,Nutku E,et al.Interleukin-9 enhances interleukin-5 receptor expression,differentiation and survival of human eosinophils[J].Blood,2000,96(6):2163-2171.

共引文献29

同被引文献28

  • 1Hanifin JM,Rajka G. Diagnostic features of atopic dermatitis [ J ]. Acta Dermatol Venereol, 1980,92:44 - 47.
  • 2Bonness S, Bieber T. Molecular basis of atopic dermatitis [ J ]. Curt Opin Allergy Clin Immunol, 2007,7 ( 5 ) : 382 - 386.
  • 3Fanciulli M, Norsworthy PJ, Petretto E,et al. FCGR3 B copy number var- iation is associated with susceptibility to systemic, but not organ-specif- ic, autoimmunity [ J ]. Nat Genet ,2007,39 ( 6 ) :721 - 723.
  • 4Chen B, Ye T, Shao Y, et al. Association between copy-number varia- tions of the human histamine H4 receptor gene and atopic dermatitis in a Chinese population[ J]. Clin Exp Dermato1,2013,38 (3) :295 - 300.
  • 5European Task Force on Atopic Dermatitis. Severity scoring of atopic dermatitis :the SCORAD Index ( consensus report of the European Task Force on Atopic Dermatitis) [ J ]. Dermatology, 1993,186 ( 1 ) : 23 - 31.
  • 6Jabeen R, Kaplan MH. The symphony of the ninth : the development and function of Th9 cells[ J]. Curt Opin Immuno1,2012,24 ( 3 ) :303 - 307.
  • 7Mosser DM,Zhang X. Interleukin-10:new perspectives on an old cyto- kine[ J]. Inmmnol Rev,2008,226( 1 ) :205 - 218.
  • 8Wasserbeuer N, Bellow M. Atopic dermatitis [ J ]. Am J Med, 2009,122 (2) :12 - 125.
  • 9Ciprandi G, De Amici M, Giunta V, et al. Serum interleukin-9 levels are associated with clinical severity in children with atopie dermatitis [J]. Pediatr Dermato1,2013,30 (2) :222 - 225.
  • 10Sismanopoulos N, Delivanis DA, Alysandratos KD, et al. IL-9 induces VEGF secretion from human mast cells and IL-9/IL-9 receptor genes are overexpressed in atopic dermatitis [ J ]. PLoS One, 2012,7 ( 3 ) : e33271.

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中国麻风皮肤病杂志
2013年 第4期

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