高压臭氧灌肠治疗腹泻型肠易激综合征的临床观察

Clinical observation of the effect of hyperbaric ozone enema therapy on diarrhea-type irritable bowel syndrome

目的观察高压臭氧灌肠治疗腹泻型肠易激综合征的疗效。方法将86例腹泻型肠易激综合征患者分为两组,基本治疗均为地衣芽孢杆菌胶囊0.5g,口服,3次/d;曲美布汀片0.2g,口服,3次/d。另外治疗组(n=43)用高压臭氧(35%浓度臭氧约250mL)溶解于250mL温生理盐水后保留灌肠30min,1次/d,10次为1个疗程;对照组(n=43)给予250mL温生理盐水保留灌肠,1次/d,10次为1个疗程。结果治疗组的腹痛、腹泻、腹胀等症状改善明显,有效率达72.1%,与对照组相比差异有统计学意义(P<0.05)。停药后3个月治疗组复发率为46.5%,明显低于对照组(P<0.01)。结论高压臭氧治疗腹泻型肠易激综合征的疗效优于对照组,无不良反应发生,值得在临床中推广应用。

Objective To analyze the effect of hyperbaric ozone enema therapy on irritable bowel syndrome （diarrhea-type）. Methods 86 cases of patients suffered from irritable bowel syndrome （diarrhea-type） were the subjects in the research, and they were divided into two groups as treatment group and control group. Two groups were all treated by the basic treatment, which were treated with 0.5g bacillus licheniformis capsule with oral administration of three times a day, and 0.2g trimebutine piece with oral administration of three times a day. The treatment group （43 patients） was treated with clysis for 30 minutes one time a day, and 10 times is a course of treatment. Where the enema was prepared by dissolving 250mL hyperbaric ozone enema in 250mL warm physiological saline, and the concentration of ozone is percent of 35. The control group （43 patients） was treated with clysis for 30 minutes one time a day, where the enema was only 250mL warm physiological saline, and 10 times is a course of treatment. Results Abdominal pain, diarrhea, bloating and other symptoms of treatment group were evidently alleviated, the response rate of which is percent of 72.1. Compared with the result of control group, there was a statistically significant difference（P 〈7 0.05）. After stopping the prescribed treatment of the treatment group for three months, the recurrence rate of irritable bowel syndrome patients was percent of 46.5, which was significantly lower than the recurrence rate for the control group （P 〈 0.01）. Conclusion Hyperbaric ozone treatment of diarrhea-type irritable bowel syndrome is much effective, where no exists the adverse reactions. As a result, it is worthy of promotion of hyperbaric ozone treatment of irritable bowel syndrome in clinic.