普伐他汀对急性心肌梗死患者的血浆金属蛋白酶-9及C反应蛋白的影响

Influence of pravastatin on IL-6,MMP-9,CRP of patients with acute myocardial infarction

目的探讨普伐他汀对急性心肌梗死患者的血浆金属蛋白酶-9及C反应蛋白的影响。方法选取我院急性心肌梗死患者80例,按治疗方法分为治疗组和对照组,每组40例。对照组给予常规调脂药物,治疗组在对照组治疗基础上给予普伐他汀治疗。测定及比较两组治疗前后血脂变化以及血浆金属蛋白酶-9及C反应蛋白水平的变化。结果治疗组治疗后TC、TG与治疗前比较差异有统计学意义(P<0.05)。治疗后,治疗组TC、TG、HDL-C、LDL-C与对照组比较差异有统计学意义(P<0.05)。治疗后两组MMP-9及CRP水平与治疗前比较,差异有统计学意义(P<0.05);治疗后,治疗组MMP-9及CRP水平与对照组比较,差异有统计学意义(P<0.05)。结论普伐他汀治疗急性心肌梗死疗效确切,可以明显减轻炎症及稳定斑块,值得在临床上推广应用。

Objective To discuss the influence of pravastatin on MMP-9,CRP of patients with acute myocardial infarction. Methods 80 patients with acute myocardial infarction in our hospital were selected and divided into treatment group and control group follow the treatment methods,each group had 40 cases. Control group was given conventional lipid drug,and treatment group was given pravastatin based on the treatment of control group. MMP- 9,CRP and blood lipid situation of two groups were determined and compared before and after treatment. Results There were significant differences on TC,TG of treatment group after treatment when compared with before treatment （P 〈 0.05）. after treatment,there were significant differences on TC,TG,HDL-C,LDL-C of treatment group compared with control group （P 〈 0.05）. There were significant differences on MMP-9 and CRP of two groups between before and after treatment（P 〈 0.05）,after treatment,there were significant differences on MMP-9 and CRP between two groups（P 〈 0.05）. Conclusion Pravastatin has a good curative effect in the treatment of acute myocardial infarction,it can reduce inflammation and stable plaque,so it is worthy to use in clinic.