血清CEA、CA125、CA153联合检测在乳腺癌诊断中的应用价值研究

Diagnosis value of combined detection of CEA、CA125、CA153 in patients with breast cancer

目的探讨血清CEA、CA125、CA153联合检测在乳腺癌诊断中的应用价值研究。方法选择乳腺癌患者作为观察组、乳腺良性疾病患者作为良性对照组、健康体检者作为健康对照组,检测外周血中CEA、CA125、CA153的含量。结果观察组患者CEA、CA125、CA153水平明显高于良性对照组和健康对照组,并且呈现出TNMⅠ期<Ⅱ期<Ⅲ期<Ⅳ期;三项指标联合检查灵敏度为87.5%、特异度为94.5%,均高于三项指标单独检测。结论 CEA、CA125、CA153联合检查能提高乳腺癌诊断的灵敏度和特异度,具有积极的临床价值。

Objective To study the value of combined detection of CEA, CA125, CA153 in patients with breast cancer. Methods Breast cancer patients as observation group, benign breast disease patients as benign control group and health people as healthy control group. Then CEA,CA125,and CA153 were detected. Results CEA,CA125,and CA153 level of observation group were significantly higher than those in benign group and healthy group and showed TNM stage Ⅰ 〈 stage Ⅱ〈 stage Ⅲ〈 stage Ⅳ.Sensitivity and specificity of combined detection of three tumor markers were 87.5% and 94.5%,which were higher than separated detection. Conclusion Combined detection of CA153,CA125,CA199 has positive value for it can improve breast cancer diagnosis sensitivity and specificity.