格列苯脲治疗新生儿糖尿病10例临床分析

Clinical analysis of 10 cases of glibenclamide treatment of neonatal diabetes mellitus

目的探讨对新生儿糖尿病患儿采用格列本脲进行治疗的效果。方法本院在2000年5月～2013年3月收治10例新生儿糖尿病患儿,对其临床资料进行分析和总结。分析格列本脲对患儿治疗的效果。结果 10例患儿的出生体重2.5～3kg,年龄3d～2个月,来院治疗时,血糖明显升高,并且伴有酮症酸的中毒症状。患儿住院以后,对其进行胰岛素治疗,改善患儿的酮症酸中毒情况。患儿的血糖降低到15mmol/L以下,再对患儿采用格列本脲进行治疗。对其中的5例患儿采用格列本脲进行治疗,用量为0.5mg/(kg·d)时,停止使用胰岛素。对患儿进行为期7个月的随访,患儿仍需要服用格列本脲,每天服用0.3mg/kg,患儿的血糖保持稳定,没有出现明显的副作用。结论有部分患儿采用格列本脲进行治疗,效果明显,不需要使用胰岛素,减轻了患儿的痛苦。所以,对新生儿糖尿病患儿采用格列本脲进行治疗,效果明显,值得临床推广应用。

Objective To analyze and discuss the effect of treatment on patients with neonatal diabetes mellitus with glibenclamide. Methods To analyze and summarize the clinical data 10 cases of neonatal diabetes mellitus patients during the period of 2000 May-2013 year in March in our hospital. Analysis of the effect of glibenclamide on the treatment of patients with. Results The birth weight of 10 patients at the age of 3days-2 months at the age of 3days-2 months was in 2.5-3 kg, to the hospital for treatment,blood glucose increased significantly,and the symptoms associated with ketosis acid poisoning.ln hospitalized patients, insulin therapy on,improved diabetic ketoaeidosis patients.The patient＂ s blood sugar was reduced to below 15 mmol/L,then treated with glibenelamide.Treatment of 5 patients with glibenclamide,dosage was 0.5 mg/（ kg . d ） ,to stop the use of insulin.For a period of 7 months of follow- up for patients,patients still need to take glibenelamide, the daily use of 0.3 mg/kg,the patients blood sugar stable,no significant side effects. Conclusion Some patients with glibenelamide treatment,obvious effect,does not require the use of insulin, and alleviate the suffering of patients.Therefore,treatment,patients with neonatal diabetes mellitus with glibenclamide effect is obvious,it is worthy of clinical application.