急性脑梗死患者血清脂蛋白相关磷脂酶A2水平的改变及其与病情的关系

Change of serum level of lipoprotein associated phospholipase A2 and its relation with condition in patients with acute cerebral infarction

目的研究急性脑梗死(ACI)患者血清脂蛋白相关磷脂酶A2(LP-PLA2)水平的改变及其与病情的关系。方法 91例ACI患者按照美国国立卫生研究院卒中量表(NIHSS)评分分为轻型ACI组(NIHSS评分<4分)、中型ACI组(4～15分)、重型ACI组(>15分)。应用酶联免疫吸附法测定ACI患者及31名正常对照者的血清LP-PLA2水平。ACI患者NIHSS评分与血清LP-PLA2水平的关系用Spearman相关分析。结果 ACI组的血清LP-PLA2水平显著高于正常对照组(P<0.01);重型ACI亚组血清LP-PLA2水平又显著高于中型ACI亚组和轻型ACI亚组(均P<0.01)。经Spearman相关分析,ACI患者的NIHSS评分与血清LP-PLA2水平呈正相关(r=0.485,P<0.001)。结论 ACI患者的血清LP-PLA2水平显著升高,病情越重者升高越明显。

Objective To research the change of serum level of lipoprotein phospholipase A2 （Lp-PLA2） and its relation with the condition in patients with acute cerebral infarction （ACI）. Methods Aeording to the national institute of health stroke seale（NIHSS） scores, 91 ACI patients were divided into the mild ACI group （NIHSS 〈 4）, moderate ACI group （4 -15） and severe ACI group （ 〉 15）. Meanwhile, the levels of LP-PLA2 were detected in the ACI patients and 31 normal controls by enzyme linked immunosorbent assay. The relationship between the NIHSS score and serum LP-PLA2 level in ACT patients was analyzed by Spearman correlation analysis. Results The level of serum LP-PLA2 in ACI group was significantly higher than that in the normal control group （P 〈 0. 01 ）. The level of serum LP-PLA2 in the severe ACI subgroup was significantly higher than that in the mild and moderate ACI subgroups （ all P 〈 0. 01 ）. The NIHSS scores was positive correlated with the level of serum LP-PLA2 in ACI patients by Spearman correlation analysis （ r = 0. 485, P 〈 O. 001 ）. Conclusions The level of serum LP-PLA2 is significantly increased in ACI patients. The more severer the pathogenetic condition is, the more higher the level of serum LP-PLA2.