血管紧张素转换酶基因插入/缺失多态性与飞行员加速度耐力的相关性研究

Research on Relationship Between Insertion/Delation Polymorphism of Angiotensin Converting Enzyme Gene and Acceleration Tolerance of Pilots.

目的探讨飞行员血管紧张素转换酶(ACE)基因插入或缺失(I/D)多态性与飞行员加速度耐力的相关性。方法用聚合酶链反应(PCR)扩增技术检测50例高+Gz耐力飞行员和32例低+Gz耐力飞行员的ACE基因I/D多态性。结果高+Gz耐力飞行员组II基因型(58.00%)和I等位基因频率(0.76)显著高于低+Gz耐力飞行员组(分别为18.75%和0.47,P<0.01)。结论 ACE I基因有可能在飞行员的+Gz耐力中起重要作用。

Objective To investigate the association of insertion/deletion （I/D） polymorphism of the angioten- sin-converting enzyme （ACE） gene with acceleration （ ＋ Gz） tolerance of pilots. Methods Polymerase chain reaction （PCR） was used to determine the genotypes for an insertion/delation （I/D） polymorphism of the ACE gene in 50 pilots with high ＋ Gz tolerance and 32 pilots with low ＋ Gz tolerance. Results The genotype II and I allele frequency were significantly higher in the pilots With high ＋ Gz tolerance （58.00% and 0.76） than that in the pilots with low ＋ Gz tolerance （ 18.75% and 0.47, P 〈 0.01 ）. Conclusion It is suggested that I gene of ACE may olav a role in ＋ Gz tolerance of pilots.