期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

白介素13-1112C>T基因多态性与广东汉族特应性皮炎的关系 被引量：1

Study on Interleukin-13 -1112 C>T gene Polymorphisms in Patients with Atopic Dermatitis in Comtonese Han Nationality
下载PDF
导出
摘要 目的对广东汉族特应性皮炎的患者行白介素13-1112C>T基因分型,探讨白介素13-1112C>T基因与本地区特应性皮炎遗传易感性的相关性。方法用PCR-RFLP法对75例广东汉族无亲缘关系的特应性皮炎患者和107例无血缘关系的健康广东汉族人行白介素13-1112C>T基因分型。结果特应性皮炎组与对照组相比,白介素13-1112C/T基因型频率差异均无统计学意义(P>0.05);白介素13-1112位点的T/T基因不存在显著相关(P>0.05)。结论白介素13-1112C>T基因多态性与广东汉族人特应性皮炎不存在相关性。 Objective To investigate the distribution of Interleukin-13-1112 C 〉 T genes in a Guangdong population and to explore the association of these genes with atopie dermatitis. Methods One hundred and Seven un- related healthy individuals of Cantonese Han nationality and 75 patients with atopic dermatitis who were from the same geographic region were enrolled in the study. The lnterleukin-13-1112 C 〉 T was genotyped by PCR-RFLP technique. Results There was no significant difference between IL-13-1112 CT and CC gene-types. There was no significant difference in IL-13-1112 between AD group and control group. Conclusion Polymorphisms of ILl 3-1112 C 〉 T were no associated with atopic dermatitis of Cantonese Han nationality.
作者 林立 徐霞 伍秋容 刘永平 杨健 杨瑞明
机构地区 广州医学院第二附属医院皮肤科 广州医学院临床免疫学教研室 广州医学院第二附属医院过敏反应科 广州医学院第二附属医院眼科
出处 《中国皮肤性病学杂志》 CAS 北大核心 2013年第5期458-460,514,共4页 The Chinese Journal of Dermatovenereology
基金 广州市医药卫生科技一般引导项目(201102A213027) 广东省科技计划项目(2010B031600139)
关键词 特应性皮炎 白介素13—1112 C〉T 基因多态性 Atopic dermatitis Interleukin-13-1112 C 〉 T Gene polymorphisms
分类号 R758.2 [医药卫生—皮肤病学与性病学]
  • 相关文献

参考文献17

  • 1Punnonen J, Aversa G, Cocks BG, et al. Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells[ J]. Proc Natl Acad Sci USA, 1993,90 ( 8 ) : 3730 - 3734.
  • 2Leung DYM, Bhan AK, Schneeberger EE, Geha RS. Characterization of the mononuclear cell infiltrate in atopic dermatitis using monoclonal antibodies[ J]. Allergy Clin Immunol, 1983,71 ( 1 Pt 1 ) :47 - 56.
  • 3Hamid Q, Naseer T, Minshall EM, et al. In vivo expression of IL-12 and IL-13 in atopic dermatitis [ J]. Allergy Clin Immunol, 1996,98 (1) :225 -231.
  • 4Beyer K, Nickel R, Freidhoff L, et al. Association and linkage of atopic dermatitis with chromosome 13q12-14 and 5q 31-35 markers [J]. Invest Dermato1,2000,115 ( 5 ) :906 - 908.
  • 5Tsunemi Y, Saeki H, Nakamura K, et al. Interleukin-13 gene polymorphism G4257A is associated with atopic dermatitis in Japanese patients[J]. Dermatol Sci,2002,30(2) :100 - 107.
  • 6He JQ, Chan-Yeung M, Becker AB, et al. Genetic variants of the IL13 and IL4 genes and atopic diseases in at-risk children[J]. Genes Immun ,2003,4(5 ) :385 - 389.
  • 7Hummelshoj T, Bodtger U, Datta P, et al. Association between an interleukin-13 promoter polymorphism and atopy[J]. Eur J Immunogenet,2003,30(5) :355 - 359.
  • 8Owczarek W, Paluchowska E, Targowski T. The relation of atopy patch tests with immunoglobulin E. Atopy patch tests with aeroallergens results dependence with the concentration of specific class E antibodies assay level assessment[J]. Pol Merkur Lekarski,26( 151 ) :35 -39.
  • 9Grunig G, Warnoek M, Wakil AE, el al. Requirement for IL-13 independently of IL-4 in experimental[J]. Asthmal Science,1998,282 (5397) :2261 -2263.
  • 10Wills-Karp M, Luyimbazi J, Xu X, et al. Interleukin-13 : central mediator of allergic [J]. Asthmal Science, 1998,282 ( 5397 ) :2258 - 2261.

二级参考文献12

  • 1Cserhati E. Current view on the etiology of childhood bronchial asthma. Orv Hetil, 1999, 140:2675-2683.
  • 2Lahiri DK, Schuable B. DNA isolation by a rapid method from human blood sample: effects of MgCl2, EDTA, storage time, and temperature no DNA yield and quality. Biochem Genet, 1993, 32:321-328.
  • 3Graves PE, Kabesch M, Halonen M, et al. A cluster of seven tightly linked polymorphisms in the IL-13 gene is associated with total serum IgE levels in three populations of white children. J Allergy Clin Immunol, 2000, 105: 506-513.
  • 4Grunig G, Warnock M, Wakil AE, et al. Requirement for IL-13 independently of IL-4 in experimental asthma. Science,1998,282: 2261-2263.
  • 5Wills-Karp M, Luyimbazi J, Xu X, et al. Interleukin-13: central mediator of allergic asthma. Science, 1998,282:2258-2261.
  • 6Zhu Z, Homer RJ, Wang Z, et al. Pulmonary expression of interleukin-13causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest, 1999,103:779-788.
  • 7Collins FS, Guyer MS, Charkravarti A. Variations on a theme: cataloging human DNA sequence variation. Science,1997,278: 1580-1581.
  • 8van der Pouw Kraan TC, van Veen A, Boeije LC, et al. An IL-13 promoter polymorphism associated with increased risk of allergic asthma. Genes Immun, 1999,1: 61-65.
  • 9Hodge MR, Ranger AM,Charles de la Brouse F, et al. Hyperproliferation and dysregulation of IL-4 expression in NF-ATp-deficient mice. Immunity, 1996, 4: 397-405.
  • 10Kiani A, Viola JP, Lichtman AH, et al. Down-regulation of IL-4 gene transcription and control of the Th2 cell differentiation by a mechanism involving NFAT1. Immunity, 1997,7:849-860.

共引文献17

同被引文献6

  • 1Kabesch M, Schedel M, Carr D, et al. IL-4/IL-13 pathway geneticsstrongly influence serum IgE levels and childhood asthma[ J ]. J AllergyClin Immunol,2006,117?2) :269 -274.
  • 2GleA J,Trzeciak M,Sobjanek M,et al. Interleukin-13 promoter p<>l-ymorphism-1112 C/T is associated with atopic dermatitis in Polish pa-tients [J]. Acta Dermatovenerol Croat ,2012,20(4) :231 -238.
  • 3Chang YT,Lee WR, Yu CW,et al. No association of cytokine gene [>oly-morphisms in Chinese patients with atopic dermatitis [ J ] . Clin Exp Der-matol,2006 ,31 (3 ) :419 -423.
  • 4Owczarek W, Paluchowska E, Targowski T, et al. The relation of atopypatch tests with immunoglobulin E. Atopy patch tests with aeroallergensresults dependence with the concentration of specific class E antibodiesassay level assessment[ J]. Pol Merkur Lekarski ,2009,26( 151) :35 -39.
  • 5Singla JP,Parashar Y. Pervalence of allergic rhinitis,allergic conjuncti-vitis and atopic dermatitis in children with recurrent wheeze[ J ]. IndianPediatr,2009,46(3) :262.
  • 6Nie W, Liu Y, Bian J,et al. Effects of polymorphisms-1112C/T a川I +2044A/G in interleukin-13 gene on asthma risk : a meta-analysis [ J 1.PLoS One,2013 ,8(2) :e56065.

引证文献1

中国皮肤性病学杂志
2013年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部