肠道抗生素行肠道准备后对大肠杆菌耐药的影响

Impact of the Escherichia coli resistant line after colorectal cancer patients with preoperative oval intestinal antibiotics for bowel preparation

目的:探讨结直肠肿瘤患者术前口服肠道抗生素行肠道准备对大肠杆菌耐药的影响。方法:对符合要求的100例结直肠肿瘤患者随机分成两组,观察组采用口服肠道抗生素1d,对照组口服肠道抗生素3d,于术中采集每例病员结肠黏膜附着物行细菌培养及药敏试验,统计两组大肠杆菌培养阳性率及其耐药情况。结果:1d组和3d组结肠黏膜附着物大肠杆菌培养阳性率分别为46%和40%,3d组大肠杆菌较1d组对丁胺卡那霉素、庆大霉素、环丙沙星及左氧氟沙星耐药增加(P<0.05);两组均对氨苄西林全部耐药,而对厄他培南、亚胺培南及哌拉西/他唑巴坦全部敏感。结论:肠道抗生素用于结直肠肿瘤患者术前肠道准备,3d方案致大肠杆菌对部分药物耐药性增加,术前肠道准备宜尽量减少服用抗生素。

AIM：To explore the impact of the Escherichia coli resistant line after colorectalcancer patients with preoperative oral intestinal antibiotics for bowel preparation. METHODS：100 cases with colorectal cancer were randomly divided into observation group and control group. The observation group （50 cases） was treated with oral intestinal antibiotics one day. The control group （50 cases） was treated with intestinal antibiotics three days. The Colonic mucosa attachments taken from all patients dur- ing operation, were bacterial cultured and sensi- tive tests. The results of the two groups were compared. RESULTS：The positive rate of colon- ic mucosa attachments Escherichia coli culture of one day group and three days group were 46 and 40%, respectively. The drug resistance of three days group of Escherichia coli was in- creased than those of one day group of amikacin,gentamicin, ciprofloxacin and levofloxacin （P〈 0.05）. Both groups were all resistant to ampicil- lin, while ertapenem, imipenem, and Paila West/tazobactam were all sensitive. CONCLU- SION- Using intestinal antibiotics for colorectal cancer patients with preoperative bowel prepara- tion, three days program increased resistance for Escherichia coli on the part of the drug. Preop- erative bowel preparation should minimize taking antibiotics.