水飞蓟宾保护胰岛β细胞的作用及机制

Protective effect and mechanism of silybin on islet β-cells

水飞蓟宾是从水飞蓟中提取的一种黄酮类天然化合物,已用于多种疾病的治疗。近年来研究显示,水飞蓟宾对胰岛β细胞具有抗氧化、抗炎、改善糖脂毒性、增加胰岛素敏感性,改善胰岛素抵抗的作用,有可能成为潜在的糖尿病防治药物。

A flavonoid extracted of milk this- tle, silybin, is the most prescribed natural com- pounds, which is increasingly used in many kinds of diseases. Recent experimental studies have clearly demonstrated the effects of silybin on islets, its antioxidant, anti-inflammatory effects, and its effect of improving glucoliptoxic-ity, as well as its protective effect of improving insulin sensitivity and ameliorating insulin re- sistance. Therefore silybin seems a promising drug for diabetes mellitus.