LASEK治疗薄角膜近视的临床疗效观察

Clinical effects of thin cornea myopia treated by LASEK

目的探讨准分子激光上皮瓣下角膜磨镶术(laser-assisted subepithelial keratomileusis,LASEK)治疗薄角膜近视的有效性和安全性。方法收集2008年2月至2010年11月于我院行LASEK的薄角膜近视患者43例(86眼),术前角膜厚度463～508(496.45±13.72)μm。术后随访12～22个月,分别于2周、1个月、2个月、6个月复查眼部症状、视力、眼压、角膜haze及角膜上皮情况。结果术后角膜上皮愈合时间为(5.74±1.64)d。术前眼压为(14.64±3.15)mmHg(1kPa=7.5mmHg),术后6个月为(14.52±2.84)mmHg,差异无统计学意义(P>0.05)。术后2周、1个月、2个月与术后6个月间不同程度haze发生率差异均有统计学意义(均为P<0.05),术后2周、1个月、2个月间不同程度haze发生率差异均无统计学意义(均为P>0.05)。术后不同时间点不同角膜厚度、屈光度组裸眼视力比较差异均无统计学意义(均为P>0.05)。结论 LASEK治疗薄角膜近视安全有效,可作为首选术式。

Objective To investigate the efficacy and safety of thin corneal myopia treated by laser-assisted subepithelial keratomileusis （LASEK）. Methods A total of 43 cases（ 85 eyes） with preoperative corneal thickness of 453 μm to 508 μm（495.45 ± 13.72） ptm,who had been treated by LASEK in our hospital from February 2008 to November 2010, were collected. The follow-up time was from 12 months to 22 months, and eye symptoms, visual acuity, intraocular pressure, corneal haze and corneal epithelium at postoperative 2 weeks, 1 month, 2 months,5 months were rechecked. Results The postoperative epithelial healing time was （5.74 ± 1.54 ） days. There was no statistical difference between the preoperative intraocular pressure （ 14.54 ± 3. 15 ） mmHg （ 1 kPa = 7.5 mmHg） and the postoperative 5 months （ 14.52 ± 2.84 ） mmHg （P 〉 0.05 ）. Incidence rates of haze at postoperative 2 weeks, 1 month,2 months and 5 months were statistical different（ all P 〈 0.05 ）, and incidence rates of haze at postoperative 2 weeks, 1 month and 2 months were not statistical different（ all P〉0.05 ）. There was no statistical difference between the different corneal thicknesses and the naked vision in diopter group at different time point （ all P 〉 O. 05）. Conclusion LASEK for thin cornea myopia is safe and effective, and can be used as the preferred surgery.