γ-干扰素加全身化疗治疗多耐药肺结核的临床观察

Clinical Observation of Treatment of Multi-drug-resistant Tuberculosis by γ-Interferon Plus Systemic Chemotherapy

目的:观察全身化疗基础上加γ-干扰素雾化吸入治疗多耐药肺结核的临床疗效。方法:选取32例患者,分为观察组和对照组,对两组患者均给予全身化疗,观察组在化疗同时,雾化吸入γ-干扰素,观察疗效。结果:在治疗6个月和治疗结束,观察组的痰细菌学检查阴转率(分别为75%和100%)均高于对照组,差异有统计学意义(P<0.05);治疗结束时,观察组病灶吸收率(93.75%)显著高于对照组(62.50%),差异有统计学意义(P<0.05);观察组空洞缩小率(93.75%)高于对照组(68.75%),差异无统计学意义(P>0.05),观察组症状改善率(68.75%)高于对照组(31.25%),差异有统计学意义(P<0.05)。结论:γ-干扰素联合全身化疗治疗多耐药肺结核效果强于单纯全身化疗。

Objective： To observe clinical effects of treatment of multi-drug-resistant tuberculosis by systemic chemotherapy based on atomizing inhalation of γ-interferon. Method： 32 patients were divided into observation group and control group, two groups of were treated with systemic chemotherapy, and patients of observation plus atomizing inhalation of γ-interferon, then effects were observed. Result： Sputum bacteriology negative rates of the observation group （ respectively 75% and 100% ） at the six-month of the treatment and end-of-treatment were higher than that in the control group, the difference was statistically significant （ P〈0.05 ） ; end of treatment, loci absorption of the observation group （ 93.75% ） was significantly higher than that of the control group （ 62.50% ）, and the difference was statistically significant （ P〈0.05 ） ; cavity narrowing rate of observation group （ 93.75% ） higher than that of the control group （ 68.75% ）, although the difference was not statistically significant （ P〉 0.05 ）, the observation group symptom improvement rate （ 68.75% ） higher than control group （ 31.25% ）, the difference was statistically significant （ P〈0.05 ） . Conclusion： γ-Interferon in combine with chemotherapy for treatment of multi-drug-resistant tuberculosis is more effective than chemotherapy alone.