联合检测胸水INF-γ、ADA、CEA、CA125在良恶性胸腔积液鉴别诊断中的价值

Value of Joint Monitoring the Levels of INF-γ,ADA,CEA,CA125 in the Differential Diagnosis of Benign and Malignant Pleural Effusion

目的:探讨胸水中INF-γ、ADA、CEA、CA125四项指标联合检测对于鉴别良恶性胸腔积液的意义和诊断价值。方法:收集2011年1月-2012年12月在笔者所在医院治疗的136例胸腔积液患者,经病理诊断分恶性组(n=75)和良性组(n=61),检测患者的胸水中CEA、CA125和INF-γ、ADA活性,并对检测结果进行比对分析。结果:恶性组肿瘤标志物CEA、CA125水平明显高于良性组,INF-γ、ADA表达水平明显低于良性组,差异具有统计学意义(P<0.05)。联合检测可显著提高诊断敏感性(93.3%)。结论:联合检测胸水中INF-γ、ADA、CEA、CA125四项指标,对鉴别良恶性胸腔积液有重要诊断意义和临床价值。

Objective： To investigate the INF-γ, ADA、 CEA、 CA125 indicators of significance and diagnostic value for differentiating benign and malignant pleural effusion.Method： Collected 136 cases of patients with pleural effusion treated in our hospital, and divided into malignant group （ n=75 ） and benign group （ n=61 ） .Compared results of INF-γ, ADA, CEA CA125 between two groups.Result： Malignancy tumor markers CEA and CA125 level of malignant group were significantly higher than those in benign group, while INF-γ , ADA expression level were significantly lower than that in benign group, with statistically significant difference （ P〈0.05 ） .Joint detection can significantly improved the diagnostic sensitivity （ 93.3% ） . Conclusion： The joint detection of INF-γ, ADA, CEA, CA125 have important diagnostic significance and clinical value in differentiating benign and malignant plenral effusion.