急性胆源性胰腺炎血浆内皮素检测的临床意义

The Clinical Significance of Detecting Plasma Endothelin in Patients with Acute Biliary Pancreatitis

目的探讨急性胆源性胰腺炎(ABP)患者血浆内皮素(ET)浓度的变化与其发病机制的关系。方法采用放射免疫分析法测定ABP患者、胆石症(GD)患者及健康人血浆ET水平并进行比较。结果 ABP患者血浆ET(80.75±13.35 pg/L)明显高于GD(61.06±9.12 pg/L)患者(P<0.01),其中重症急性胰腺炎(SAP)患者血浆ET(85.95±14.91 pg/L)明显高于轻型急性胰腺炎(MAP)患者血浆ET(69.43±12.61 pg/L),(P<0.01)。结论血浆ET在ABP发病过程中起重要作用,测定ABP患者血浆ET水平对临床诊断和治疗有重要临床意义。

Objective Investigated the changes of the plasma endothlin （ET）in order to better understand the pathogenesis of the acute biliary pancreatitis （ABP）. Methods Radioimmunoassay was used to measured the plasma ET level of the ABP patients, gallstonedisease （GD） patients and healthy people. Results In comparison with GD patients（61.06 ± 9.12 pg/L） ,ET level of the ABP patients（80.75 ± 13.35 pg/ L） was signifcantly higher （P 〈 0. 01 ）, and severe acute pancreatitis （SAP） plasma ET level （ 85.95 ± 14.91 pg/L） was higher than mild acute pancreatitis（MAP） （69.43 ± 12.61 pg/L） （P 〈 0.01 ）. Conclusion The plasma ET plays an important role in the process of the ABP disease, and measured the plasma ET level can guideline the clinical diagnosis and treatment of the ABP patients.