根治术后胃癌组织中肽基脯氨酰顺反异构酶1及细胞周期素E的表达及意义

The expression of PIN 1 and Cyclin E in gastric carcinoma tissue after radical gastrectomy and its significance

目的 探讨根治术后胃癌组织中肽基脯氨酰顺反异构酶1（PIN1）及细胞周期素E（Cyclin E）的表达及意义。方法 选择46例接受胃癌根治术的患者作为研究对象,取其肿瘤组织作为胃癌组,癌旁正常组织作为对照组,采用免疫组织化学法观察组织中PIN1以及Cyclin E的表达情况,并分析其与肿瘤浸润深度、分化程度、淋巴及远处转移等病理参数的关系并对患者进行为期5年的随访调查。结果 胃癌组织中PIN1（3 949.66±157.40）及Cyclin E（5 443.07±240.15）表达显著高正常组织［（247.67±75.63）、（354.92±93.88）］（均P＜0.05）,其中PIN1与胃癌分化程度、淋巴及远处转移有关;Cyclin E则与胃癌浸润深度及分化程度有关;PIN1及Cyclin E表达同时升高的患者5年生存率仅为50.0%,显著低于两者表达单独升高或不升高者。结论 胃癌根治术后胃癌组织中PIN1及Cyclin E表达水平升高,可较好反映病理参数及预后。

Objective To explore the expression of PIN1 and Cyclin E in gastric carcinoma tissue after radical gastrectomy and its significance.Methods 46 patients received radical gastrectomy were selected as study subjects.Cancer tissues were harvested as the gastric cancer group,and the adjacent normal tissues of tumor tissue were harvested as the control group.The expression of PIN1 and Cyclin E was observed by immunohistochemistry,and the relationship with tumor infiltration,differentiation,lymphatic and distant metastasis were analyzed.A five year follow-up study was also applied.Results The expression of PIN1 （3 949.66±157.40）and Cyclin E （5 443.07±240.15） was significantly higher than those of the control group[（247.67±75.63）,（354.92±93.88）]（all P〈0.05）,and the expression of PIN1 was related with tumor differentiation,lymphatic and distant metastasis,and the expression of Cyclin E was closely related with tumor infiltration and differentiation.The 5-year survival rate of patients with the simultaneously increased expression of PIN1 and Cyclin E was 50.0%,which was significantly lower than the expression of the two separate elevated or not elevated.Conclusion The expression of PIN1 and Cyclin E in cancer tissues after radical gastrectomy is high,and could better reflect the pathological parameters and prognosis.