他汀类药物辅助治疗脑梗死108例疗效分析

Clinical analysis of effects of statins in adjuvant treatment of 108 patients with cerebral infarction

目的 探讨他汀类药物对脑梗死患者的治疗效果以及对脑梗死复发的预防效果。方法 高血压动脉粥样性脑梗死患者108例,采用数字表法随机分为两组,每组54例。对照组采用常规治疗;观察组在常规治疗的基础上给予他汀类药物联合治疗。2个月后进行疗效评价,观察两组患者的血脂改善情况,比较两组的临床疗效,并统计两组患者在治疗后1年内脑梗死的复发情况。结果 观察组治疗后血脂等各项指标均优于对照组（均P＜0.05）;观察组总有效率100%,高于对照组的76%（χ^2=9.488,P＜0.05）;对照组复发12例（复发率22%）,观察组复发1例（复发率2%）,两组差异无统计学意义（χ^2=13.277,P＜0.05）。结论 他汀类药物治疗和预防高血压动脉粥样性脑梗死有效、安全,值得在临床上推广使用。

Objective To explore the effect of statin in treatment of hypertensive atherosclerotic patients with cerebral infarction and the its effect in prevention cerebral infarction recurrence.Methods 108 hypertension patients with atherosclerotic cerebral infarction were randomly divided into two groups,each group had 54 cases.The control group received conventional treatment;the observation group was given combination therapy with statin and the conventional treatment.The efficacy was evaluated after 2 months.The blood pressure,blood lipid and cerebral function,cerebral infarction recurrence within 1 year after treatment in the two groups were observed.The clinical efficacy of the two groups was compared.Results After treatment,blood pressure,blood lipid indexes and brain function of the observation group were better than those of the control group（all P〈0.05）.The total effective rate of the observation group was 100%,which was higher than 76% in the control group（χ^2=9.488,P〈0.05）.The control group had 12 cases of recurrence（recurrence rate 22%）,1 case recurrence in the observation group（recurrence rate 2%）,with no significant difference between two groups（χ^2=13.277,P〈0.05）.Conclusion The clinical efficacy of statins in the treatment and prevention of hypertension atherosclerotic cerebral infarction is safe and significant,which is worth to use in clinical practice.