摘要
目的 探讨乌司他丁对肺部手术患者肺损伤的保护作用及对炎症的影响。方法 将接受肺叶切除术的36例患者平均分为对照组与观察组,均接受气管插管全身麻醉,通气方式为单肺通气(OLV),观察组还接受乌司他丁治疗。在不同时间点观察并比较两组患者血浆白细胞介素-6(IL-6)、IL-10以及肿瘤坏死因子-α(TNF-α)水平,采用免疫组织化学对肺组织水通道蛋白-4(AQP-4)表达量进行检测。结果 与OLV开始前相比,随着时间的推移,OLV开始后两组患者血浆IL-6、TNF-α以及IL-10水平均显著升高(均P<0.05);观察组在各时间点IL-6及TNF-α水平均显著低于对照组(均P<0.05),IL-10差异无统计学意义(P>0.05);与对照组相比,观察组肺组织AQP-4水平显著升高(t=10.29,P<0.05)。结论 在肺部手术时使用乌司他丁可显著抑制体内炎性反应水平,并通过提高AQP-4蛋白表达水平等代偿机制对肺起保护作用。
Objective To explore protective effects of ulinastatin on lung injury and inflammation in patients received pulmonary surgeries.Methods 36 patients received pulmonary surgeries were randomly divided into control group and experimental group,and OLV was applied during surgeries.Additionally,ulinastatin was given to experimental group.Serum levels of IL-6,IL-10 and TNF-alpha were observed at different time after OLV by ELSIA.The expression of AQP-4 was observed by immunohistochemistry.Results Serum levels of IL-6,IL-10 and TNF-alpha increased significantly in all patients after OLV was applied(P〈0.05).The levels of IL-6 and TNF-alpha increased more significantly in experimental group than control group at all time points.The expression of AQP-4 increased significantly in experimental group than control group(t=10.29,P〈0.05).Conclusion Conclusion Ulinastatin shows protective effects on lung injury during pulmonary surgeries,mainly via attenuating inflammation reactions and expression of AQP-4.
出处
《中国基层医药》
CAS
2013年第10期1474-1476,共3页
Chinese Journal of Primary Medicine and Pharmacy
关键词
乌司他丁
急性肺损伤
炎症
Ulinastatin
Acute lung injury
Inflammation