血必净治疗百草枯中毒疗效观察

Observation on the effect of Xuebijing injection in treatment of acute paraquat poisoning

目的 观察血必净注射液对急性百草枯中毒患者脏器损害的保护作用。方法 将30例急性百草枯中毒患者按数字表法随机分为两组。对照组单纯给予常规及血液灌流治疗,治疗组在对照组的基础上给予血必净治疗,对两组临床疗效及血氧饱和度、肝肾功能进行分析。结果 治疗组血氧饱和度、肝肾功能指标均明显优于对照组。治疗组2例放弃治疗,治愈9例,死亡4例,总有效率为60.0%;对照组1例放弃,治愈4例,死亡10例,总有效率为26.7%。两组总有效率差异有统计学意义（χ^2=4.75,P＜0.05）。结论 血必净注射液对百草枯中毒导致的多脏器损伤疗效较好,值得临床推广。

Objective To observe the effect of Xuebijing injection on organs injury in patients with acute paraquat poisoning.Methods Thirty patients with paraquat poisoning were randomly divided into two groups.The improvement of liver and kidney function,SaO2,rate of death were observed and compared between the two groups.Results The ABG,SaO2,GGT and Crea were all improved significantly in the treatment group than control group.At last,two patients gave up their treatment,nine cases were cured,four cases died in treatment group.One patient gave up treatment,four cases were cured,ten cases died in control group.The total effective rate of the treatment group and control group was 60.0%,26.7%,the difference was significant（χ^2=4.75,P〈0.05）.Conclusion Xuebijing injection has very good clinical effect in multiple organ failure of paraquat poisoning,it is worthy of clinic application.