纤溶酶联合阿司匹林治疗急性脑梗死的疗效观察

Observation on the effect of plasmin combined with aspirin in the treatment of acute cerebral infarction

目的 观察纤溶酶联合阿司匹林治疗急性脑梗死的临床疗效,并探讨其对血液流变学和神经功能恢复的影响。方法 选择148例急性脑梗死患者,按数字表法随机分为两组,观察组（74例）给予纤溶酶联合阿司匹林治疗,对照组（74例）给予红花注射液治疗,观察两组的临床疗效,同时观察两组患者治疗前后血液流变学改变和神经功能恢复情况。结果 观察组总有效率为97.2%,显著高于对照组的74.3%（χ2=15.88,P＜0.05）。两组血液流变学指标均有改善,但观察组更显著（t=3.56、3.42、4.26、3.22,均P＜0.05）;两组患者经治疗后神经功能均有所恢复,但观察组恢复更明显（t=4.16,P＜0.05）。结论 纤溶酶与阿司匹林联合应用在治疗急性脑梗死方面临床疗效确切,能显著改善血液流变学指标,促进神经功能恢复,值得临床推广和普及。

Objective To observe the clinical effect of plasmin combined with aspirin in treating acute cerebral infarction and to explore the influence to blood rheology and nerve function.Methods 148 cases with acute cerebral infarction were randomly divided into two groups.The control group （n=74） was treated by honghua injection.The study group （n=74） was treated by plasmin combined with aspirin.After treatment,the clinical effect,blood rheology and neurological recovery were observed.Results The total effective rate of the study group was 97.2%,which was significantly higher than that of the control group（74.3%）（χ2=15.88,P〈0.05）.The blood rheology indexes of the two groups had improved and neural function of the two groups was restored,but those in the study group were obviously better than control group（t=3.56,3.42,4.26,3.22,4.16,all P〈0.05）.Conclusion Plasmin combined with aspirin in treating acute cerebral infarction has accurate clinical curative effect,can markedly improve the blood rheology and promote nerve functional recovery,is worth of clinical spreading.