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哺乳动物肽聚糖识别蛋白抗菌作用及其机制的研究进展 被引量：1

Progress of Researches on Antibacterial Functions and Mechanisms of Mammalian Peptidoglycan Recognition Proteins
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摘要 哺乳动物肽聚糖识别蛋白(PGRPs)是一类可识别肽聚糖的免疫激活分子,具有抗菌活性。它的抗菌机制与其他抗菌肽明显不同。最新研究发现,哺乳动物PGRPs通过与肽聚糖结合,激活在细菌中识别胞浆外错误折叠蛋白质分子的CssR-CssS或CpxA-CpxR双部件系统,最终导至细菌死亡。文中总结了肽聚糖识别蛋白的抗菌作用及其机制的相关研究进展。 Mammalian peptidoglycan recognition proteins （PGRPs） were a kind of innate immunity molecules, which could recognize peptidoglycan and had antibacterial activities. However, the antibacte- rial mechanism of PGRPs was different from most antibacterial peptides. The latest findings indicated that mammalian PGRPs could activate the CssR-CssS two-component system, which finally resulted in bacteri- al death. This review focused on the antibacterial activities and mechanisms of PGRP.
作者 郭睿 王银
机构地区 扬州大学兽医学院
出处 《吉林农业大学学报》 CAS CSCD 北大核心 2013年第2期236-240,共5页 Journal of Jilin Agricultural University
基金 教育部博士点基金项目(02318962023532)
关键词 肽聚糖识别蛋白 杀菌 CssR-CssS PGRPs antibacterium CssR-CssS
分类号 S852.6 [农业科学—基础兽医学]
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参考文献26

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  • 2黄种彬.采血应激对蛋鸭产蛋性能影响的研究[J].福建畜牧兽医,2005,27(6):19-19. 被引量：3
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吉林农业大学学报
2013年 第2期

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