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The balancing act of AKT in T cells

The balancing act of AKT in T cells
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摘要 Abstract The serine/threonine-specific protein kinase AKT is gaining recognition as a major crossroad in numerous cellular signaling pathways through its ability to regulate cell differentiation, proliferation, survival and metabolism. This review focuses on the recent advances in AKT signaling and downstream events in T cells, emphasizing its contrasting role in conventional and regulatory （Treg） T cell populations. Activation of AKT has been known for many years to be critical in the development and function of conventional T cells. However, it has just recently been uncovered that AKT exerts an inhibitory effect on Treg generation and suppressor function. These studies have placed AKT at the nexus of Treg development and function, thus opening novel avenues for therapeutic manipulation. Abstract The serine/threonine-specific protein kinase AKT is gaining recognition as a major crossroad in numerous cellular signaling pathways through its ability to regulate cell differentiation, proliferation, survival and metabolism. This review focuses on the recent advances in AKT signaling and downstream events in T cells, emphasizing its contrasting role in conventional and regulatory （Treg） T cell populations. Activation of AKT has been known for many years to be critical in the development and function of conventional T cells. However, it has just recently been uncovered that AKT exerts an inhibitory effect on Treg generation and suppressor function. These studies have placed AKT at the nexus of Treg development and function, thus opening novel avenues for therapeutic manipulation.
作者 Mary Catherine RENEE~ Francesc MARTI
机构地区 Department of Microbiology
出处 《Frontiers in Biology》 CAS CSCD 2013年第2期160-174,共15页 生物学前沿（英文版）
关键词 AKT TREGS T cell signaling T cell differentiation AKT, Tregs, T cell signaling, T cell differentiation
分类号 Q2 [生物学—细胞生物学] Q255 [生物学—细胞生物学]
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  • 1Akbar A N, Vukmanovic-Stejic M, Taams L S, Macallan D C (2007). The dynamic co-evolution of memory and regulatory CD4+ T cells in the periphery. Nat Rev Immunol, 7(3): 231-237.
  • 2Alessi D R, Cohen P (1998). Mechanism of activation and function of protein kinase B. Curr Opin Genet Dev, 8(1): 55-62.
  • 3Alessi D R, Pearce L R, Garcia-Martinez J M (2009). New insights into mTOR signaling: mTORC2 and beyond. Sci Signal, 2(67): pc27.
  • 4Altomare D A, Guo K, Chang J Q, Sonoda G, Walsh K, Testa J R (1995). Cloning, chromosomal localization and expression analysis of the mouse Akt2 oncogene. Oncogene, 11(6): 1055-1060.
  • 5Andjelkovie M, Jakubowicz T, Cron P, Ming X F, Han J W, Hemmings B A (1996). Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors. Proc Natl Acad Sci USA, 93(12): 5699-5704.
  • 6Annacker O, Pimenta-Araujo R, Burlen-Defranoux O, Barbosa T C, Cumano A, Bandeira A (2001). CD25+ CD4+ T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10. J Immunol, 166(5): 3008-3018.
  • 7Apostolou I, Sarukhan A, Klein L, von Boehmer H (2002). Origin of regulcdory T cells with known specificity for antigen. Nat Immunol, 3(8): 756-763.
  • 8Arimura Y, Shiroki F, Kuwahara S, Kato H, Dianzani U, Uchiyama T, Yagi J (2004). Akt is a neutral amplifier for Th cell differentiation. J Biol Chem, 279(12): 11408-11416.
  • 9Balendran A, Casamayor A, Deak M, Paterson A, Gaffney P, Currie R, Downes C P, Alessi D R (1999). PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2. Curr Biol, 9(8): 393-404.
  • 10Beals C R, Sheridan C M, Turck C W, Gardner P, Crabtree G R (1997). Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3. Science, 275(5308): 1930-1933.
Frontiers in Biology
2013年 第2期

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