立普妥联合甘乐对老年非酒精性脂肪肝患者血生化及肝脏超声的影响

Effect of lipitor combined with ganle on blood biochemistry and liver ultrasound in elderly patients with nonalcoholic fatty liver disease

目的观察阿托伐他汀(立普妥)联合复方二氯醋酸二异丙胺(甘乐)对老年非酒精性脂肪肝(NAFLD)患者血生化及肝脏超声的影响。方法 2010年9月至2012年1月我院NAFLD患者106例,口服立普妥(10 mg,每晚1次)、甘乐(40 mg,3次/d),3个月为1个疗程。观察治疗前后TG、TC、ALT、AST及肝脏超声变化。结果治疗3个月后,TG、TC、ALT、AST及肝脏超声均显著改善(P<0.01)。结论立普妥联合甘乐可使老年NAFLD患者肝功能、血脂及肝脏超声影像显著改善,且无明显不良反应。

Objective To observe the effect of atorvastatin （lipitor）combined with compound diisopropylamine dichloroacetate （ganle）on blood biochemistry and liver ultrasound in elderly patients with nonalcoholic fatty liver disease（NAFLD）. Methods 106 NAFLD patients of our hospital from September 2010 to January 2012 were given lipitor（ 10 mg qn. ）and ganle （40 mg,tid）. The treatment lasted for 3 months. The changes of TG,TC,ALT,AST and liver ultrasound were recorded before and after treatment. Results After 3 months of treatment, the TG, TC, ALT, AST and liver ultrasound were significantly improved （ P 〈 0. 01 ）. Conclusion Lipitor combined with ganle can improve the liver function,blood lipids and liver ultrasound image of elderly patients with NAFLD without apparent adverse reaction.