盐酸氨溴索静脉注射辅助治疗AECOPD的疗效观察

Efficacy of ambroxol hydrochloride intravenous injection adjunctive treatment for acute exacerbation of chronic obstructive pulmonary disease

目的观察盐酸氨溴索注射液对慢性阻塞性肺疾病急性加重期(AECOPD)患者的辅助治疗作用。方法选取2009年1月至2012年10月在我院治疗的80例AECOPD患者,随机分为观察组和对照组,每组40例。对照组给予常规治疗,观察组在常规治疗的基础上加用盐酸氨溴索注射液30 mg,2次/d静脉注射。观察两组治疗后的临床疗效及不良反应发生情况。结果治疗后观察组总有效率为95%,对照组总有效率为82.5%,两组比较差异具有统计学意义(P<0.05)。治疗后观察组动脉血气指标较对照组明显改善,两组比较差异具有统计学意义(P<0.05)。两组均未发生明显的不良反应。结论盐酸氨溴索静脉用药辅助治疗AECOPD疗效显著,药物不良反应小,安全可靠。

Objective To observe the clinical efficacy of ambroxol hydrochloride injection on acute exacerbation of chronic obstructive pulmonary disease. Methods 80 patients with acute exacerbation of chronic obstructive pulmonary disease in our department from January 2009 to October 2011 were selected. The patients were randomly divided into observation group and control group with 40 cases in each group. Observation group was given conventional therapy plus ambroxol hydrochloride 30 mg intravenous injection twice a day. Control group was only given conventional therapy. The clinical efficacy and arterial blood gas of the two groups were compared after treatment. Results After treatment, the total effective rate of observation group and control group were 95 % and 82. 5 % respectively, there was significant difference between the two groups （ P 〈 0. 05 ）. Compared with control group, arterial blood gas index of the observation group was significantly increased （ P 〈 0. 05 ）. Conclusion Ambroxol hydrochloride intravenous injection adjunctive treatment for acute exacerbation of chronic obstructive pulmonary disease has good efficacy with few side effects, it is safe and reliable.