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滤泡辅助性T细胞与皮肤病 被引量:2

T follicular helper cells and some skin diseases
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摘要 滤泡辅助性T细胞是一种辅助B细胞参与体液免疫的CD4+T细胞亚群,主要通过其表达的一些分子,如趋化因子受体5、可诱导共刺激分子、B细胞淋巴瘤分子-6、白介素21等,使滤泡辅助性T细胞迁移至生发中心,与B细胞相互作用,刺激B细胞产生抗体,被认为是B细胞最主要的辅助细胞。近年研究发现,滤泡辅助性T细胞与部分皮肤病的发生发展、治疗和预后有着重要的意义。 T follicular helper (Ttla) cells are a novel subset of CD4+ T cells that provide helper functions to B ceils in humoral immune response. They may migrate into germinal center (GC) to stimulate B cells to produce antibodies under the effect of some molecules expressed by themselves, such as CXC chemokine receptor 5 (CXCR5), inducible T-cell co-stimulator (ICOS), B cell lymphoma-6 (hcl-6), interleukin (IL)-21, and so on. Currently, Till cells are considered to be the major cell helping B cells. Recent studies have shown that Tfh cells are of great significance to the development, treatment and prognosis of some skin disorders.
出处 《国际皮肤性病学杂志》 2013年第3期166-168,共3页 International Journal of Dermatology and Venereology
基金 国家自然科学基金(30700718) 徐州市社会发展科技计划项目(XF10C057)
关键词 T淋巴细胞 辅助诱导 皮肤疾病 T-lymphocytes, helper-inducer Skin diseases
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