摘要
滤泡辅助性T细胞是一种辅助B细胞参与体液免疫的CD4+T细胞亚群,主要通过其表达的一些分子,如趋化因子受体5、可诱导共刺激分子、B细胞淋巴瘤分子-6、白介素21等,使滤泡辅助性T细胞迁移至生发中心,与B细胞相互作用,刺激B细胞产生抗体,被认为是B细胞最主要的辅助细胞。近年研究发现,滤泡辅助性T细胞与部分皮肤病的发生发展、治疗和预后有着重要的意义。
T follicular helper (Ttla) cells are a novel subset of CD4+ T cells that provide helper functions to B ceils in humoral immune response. They may migrate into germinal center (GC) to stimulate B cells to produce antibodies under the effect of some molecules expressed by themselves, such as CXC chemokine receptor 5 (CXCR5), inducible T-cell co-stimulator (ICOS), B cell lymphoma-6 (hcl-6), interleukin (IL)-21, and so on. Currently, Till cells are considered to be the major cell helping B cells. Recent studies have shown that Tfh cells are of great significance to the development, treatment and prognosis of some skin disorders.
出处
《国际皮肤性病学杂志》
2013年第3期166-168,共3页
International Journal of Dermatology and Venereology
基金
国家自然科学基金(30700718)
徐州市社会发展科技计划项目(XF10C057)