癫痫生物标记物的筛选

The choice of epileptic biomarkers

癫痫是一种发作性疾病,发作间期一般没有异常,此时体格检查对诊断没有帮助,而临床医生几乎很少有机会目睹患者的发作,因而癫痫诊断在多数情况下依靠患者提供病史,而病史提供又受到患者发作时意识障碍而不能回忆的影响,可靠性受到限制。因而,研究癫痫生物标记物就成为扭转目前癫痫诊治中困难局面的有效手段。最近几年来,癫痫生物标记物的研究已取得了一些进展,了解这些进展,将帮助我们更好的认识癫痫的存在。

Epilepsy is a paroxysmal disorder. During the interictal phase, the patients look normal and physical examination is not useful for diagnosis. The clinicians rarely have a chance to witness the seizure. Thus, the diagnosis of epilepsy mostly relies on patient＇s medical history. However, reliability of the medical history is limited because patients cannot recall due to their disturbance of consciousness during the seizure. Therefore, detection of epileptic biomarkers may improve the situation. In recent years, researches on epileptic biomarkers have made some progress. These advances will helo us further understand the disease_