摘要
目的探讨血清同型半胱氨酸(Homocysteine,Hcy)、白介素18(Interleukin-18,IL-18)和高敏C反应蛋白(high-sensitivity C reaction protein,hsCRP)在2型糖尿病(type 2 Diabetic mellitus,T2DM)肾病发生、发展机制中的作用及临床意义。方法选择97例T2DM患者,根据尿白蛋白排泄率(urinary albumin excretion rate,UAER)分为正常蛋白尿组(UAER<20μg/min)35例、微量蛋白尿组(UAER 20~200μg/min)30例和大量蛋白尿组(UAER>200μg/min)32例,采用酶联免疫吸附法(ELISA)检测Hcy、IL-18水平,免疫比浊法测定hsCRP,同时测定尿素氮(BUN)、血肌酐(SCr)、UAER,与同期35例健康体检正常者(对照组)进行比较。结果 3组患者血清Hcy、IL-18和hsCRP水平明显高于对照组(P<0.01);Hcy、hsCRP、IL-18与BUN、Scr、UAER均呈正相关(P<0.01),而Hcy、IL-18分别与hsCRP呈正相关(P<0.01)。结论血清Hcy、IL-18和hsCRP可能参与了T2DM肾病的发生、发展,联合检测三者水平可能对评估早期糖尿病肾病有意义。
Objective To explore the roles of serum Hey, interleukin-18 (IL-18) and High-sensitivity C reaction protein (hsCRP) in the pathogenesis and progress of nephropathy among type 2 diabetic patients. Methods A total of 97 patients with type 2 diabetes mellitus (T2DM) were divided into three groups according to the urinary albumin excretion rate (UAER) :normal albuminuria group ( UAER〈20 I^g/min,n = 35 ), miero-albuminuria group ( UAER20 N 200 Ixg/min, n = 30 ) and macro-albuminuria ( UAER〉 200/~g/min, n = 32). Thirty-five healthy subjects were used as controls. Serum levels of Hcy and interleukin-18 were measured by en- zyme linked immunosorbent assay (ELISA) and hsCRP levels were measured by immuno-turbidimetry. Blood urea nitrogen (BUN), and serum creatinine (SCr) levels together with UAER were also determined. Results Serum levels of Hcy,IL-18 and hsCRP in the diabetic patients were significantly higher than those in the controls (P〈 0.01)Serum levels of Hey, IL-18 and hsCRP were positively correlated with BUN, SCr and UAER (P 〈 0. 01 ). Serum levels of Hey and IL-18 were also positively correlated with hsCRP( P 〈 0.01 ). Conclusions Serum Hcy, IL-18 and hsCRP may play important roles in the pathogenesis and development of DM. Combina- tion of detection of these factors might be useful in evaluation of early DM.
出处
《实用医院临床杂志》
2013年第3期65-67,共3页
Practical Journal of Clinical Medicine
关键词
2型糖尿病
糖尿病肾病
白介素18
高敏C反应蛋白
同型半胱氨酸
Type 2 Diabetic mellitus
Diabetic nephropathies
Interleukin-18
High-sensitivity C reaction protein
Homocys-teine