硝苯地平联合丹参治疗轻中度妊娠期高血压综合征的疗效及对凝血功能和血液流变学的影响

The curative effect of nifedipine combined with salvia miltiorrhiza for patients with mild and moderate gestation hypertension syndrome and impact on the coagulation-function and hemorheology

目的探讨硝苯地平联合丹参治疗轻中度妊娠期高血压综合征(妊高征)的临床疗效,以及对患者凝血功能和血液流变学指标的影响。方法将80例患者分为观察组和对照组各40例,均行常规治疗,对照组在此基础上加用硝苯地平,观察组加用硝苯地平和丹参注射液,疗程14天。观察两组临床疗效、凝血功能和血液流变学的变化。结果观察组总有效率明显高于对照组,差异有统计学意义(P<0.05)。治疗后两组患者凝血酶原时间(PT)、凝血活酶时间(APTT)均较治疗前显著上升(P<0.05);全血黏度、血浆黏度、红细胞压积和纤维蛋白(Fbg)水平较治疗前显著下降(P<0.05),但观察组患者改善幅度更显著(P<0.01)。结论硝苯地平联合丹参治疗轻中度妊高征具有较好的临床治疗效果,改善患者凝血功能和血液流变学异常,安全性高,值得临床推广应用。

Objective To investigate the clinical curative effects of nifedipine combined with salvia miltiorrhiza for patients with mild and moderate pregnancy-induced hypertension syndrome （PIH） and the impact on coagulation function and hemorrheologic indexes. Methods Eighty patients were randomly divided into observation group and control group,40 patients each. All the patients were treated with conventional therapy. The control group was supplemented with nifedipine,while the observation group supplemented with nifedipine and salvia mihiorrhiza injection. The course of treatment was 14 days. The clinical curative effects and the changes in coagulation-function and hemorheology between the two groups were compared. Results The total effective rate of patients in the obser- vation group was 90%, significantly higher than that of the control group （70%） （ P 〈 0.05 ）. After treatments, in all patients the plasma prothrombin time （PT） and activated partial thromboplastin time （AF1T） were significantly higher,while fibrin （Fbg） levels were significantly lower after the treatment than those before treatments （P 〈 0. 05）. However,the improvement of these parameters in the observation group was significantly better than that of the control group （P 〈 0. 01 ）. Moreover,in all patients the whole blood vis- cosity,plasma viscosity, and hematocrit were significantly decreased after treatment compared to treatment before （P 〈 O. 05）. Again, the observation group were decreased more significantly （P 〈 0. 01 ）. Conclusions The combination of salvia mihiorrhiza with nife- dipine in the treatment of mild and moderate PIH has good clinical therapeutic effects to improve coagulation-functional and hemorrheo- logic abnormalities. Therefore, it is highly safe and worthy of clinical application.