植入用缓释氟尿嘧啶治疗进展期胃癌安全性及效果观察

The safety and effect of sustained-release-fluorouracil for patients with advanced gastric cancer

目的评价缓释5-氟尿嘧啶治疗进展期胃癌的安全性及临床效果。方法 96例行胃癌根治术患者分成治疗组和对照组各48例,治疗组手术完毕后在瘤床和沿淋巴引流途径分多点植入缓释氟尿嘧啶,对照组术毕用5-氟尿嘧啶2000mg腹腔冲洗。观察两组术后伤口愈合情况,有无吻合口瘘、肠梗阻、腹膜炎和肝肾功能变化等。结果两组术后吻合口瘘、肠梗阻、腹膜炎以及肠功能恢复时间等方面比较差异均无统计学意义(P>0.05),而白细胞、血小板计数均较术前有明显增高(P<0.05),但两组间比较差异无统计学意义(P>0.05)。结论中晚期胃癌术中腹腔植入缓释氟尿嘧啶是安全的,具有良好的耐受性。

Objective To assess the safety and effect of intraperitoneal chemotherapy with sustained-release-fluorouracil for patients with advanced gastric cancer. Methods Ninety-six patients undergone radical operation for advanced gastric cancer were ran- domly divided into controlled group and treatment group ,48 cases each. In the treatment group, sustained-release-fluorouracil was mul- tiple implanted after the tumor was surgically removed while 2000 mg fluorouracil was used to irrigate peritoneal cavity in the control group. Afterwards, the incidence of wound infection, anastomosis leakage, intestinal obst ruction, and peritonitis were compared between the two groups. At the same time, WBC, RBC, ALT,local recurrence rate and metastasis rate were also compared. Results The differ- enee of side effects and postoperative complications between the two groups was not significant. There was a different before and after operation in WBC, ALT and Cr, but not reached significant. Conclusions The intraperitoneal chemotherapy with sustained-release flu- orouraeil during operation for advanced gastric cancer is safe, and it might become a new effective method to prevent postoperative local recurrence of gastric cancer.