中枢性低钠血症42例临床分析

Clinical analysis of 42 patients with central hyponatremia

目的探讨中枢性低钠血症的诊断和治疗特点。方法回顾性分析2007年6月至2012年6月收治的42例中枢性低钠血症患者的诊断和治疗资料。结果脑性耗盐综合征35例,抗利尿激素分泌不当综合征7例,治愈41例,1例转院治疗死亡。结论中枢性低钠血症常发生于严重脑外伤及鞍区肿瘤术后的患者,脑性耗盐综合征与抗利尿激素分泌不当综合征临床症状相似,治疗方法不同。严格监测水盐平衡,早期发现和鉴别中枢性低钠血症的分型,及时进行针对性个体化治疗,能有效防止严重的神经系统及循环系统并发症。

Objective To investigate the characteristics of diagnosis and treatment of central hyponatremia. Methods The di- agnostic and therapeutic data of the 42 central hyponatremia cases between June, 2007 and June,2012 were retrospectively analyzed. Results Of these patients ,35 patients suffered from cerebral salt wasting syndrome, and 7 syndrome of inappropriate antiduretic hor- mone secretion. All the cases were fully cured except I death that had been previously transfei＇red to other hospital. Conclusions Central hyponatremia often happens in patients with severe traumatic brain injury and post-operative patients with sellar tumors. They share very similar clinical symptoms but require different treatments. The strict water-and-salt balance monitoring, early diagnosis and i- dentification of the types of central hyponatremia, and personalized special treatments will be able to prevent the severe medical compli- cations of the nervous and Circulatory system.