射频消融过程中肝组织热传导效应的模拟实验研究

Simulation research of "heat conduction effect" of liver tissue during radiofrequency ablation

目的探讨射频消融（RFA）热量在周围肝脏组织中的热传导效应（HCE）及其有效作用范围。方法以离体猪肝为实验对象，模拟射频消融在肝组织中的热传导效应，记录猪肝组织在不同温度热源及作用时间下，热源中心向外辐射的温度场随时间的衰减规律，观察肝脏表面色泽及形态变化并记录范围数据。结果肝组织热源中心温度70℃以上时，在10min以内有效作用半径均达到smm，若继续增大至10mm，则热源温度需维持在80～90℃以上，其中80℃时维持近40min才会达到治疗温度（〉55℃），而90℃仅需要25min。结论当热源温度维持在80～90℃时，持续25～40min，热传导效应可使周围肝组织10mm范围达到55℃以上的治疗温度。

Objective To explore the heat conduction effect （HCE） and effective extent in liver tissue produced by radiofrequency ablation （RFA）. Methods To simulate the HCE produced by RFA, isolated swine livers were heated to different temperature for a range of different heating time with RFA. The temperature of liver in different distance away from the center and the changes in color and morphology of liver tissue after radiofrequency treatment were recorded to explore the attenuation pattern of different heating center temperature and duration of treatment. Results When the temperature of heating center reached 70℃, 5mm in radius of liver tissue was ablated in 10min. To expand the range to 10mm, central temperature should be maintained above 80℃ or 90℃, and the heating time should be maintained for 40min and 25min, respectively. Conclusion To complete ablation of an area of liver tissue with 10mm in diameter with HCE, the temperature of heating center should be maintained at higher than 80- 90℃ and the ablation time should be maintained for 25-40min.