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口腔鳞状细胞癌患者血清中IL-27的表达及临床意义 被引量：2

Expression and clinical significance of serum interleukin-27 level in patients with oral squamous cell carcinoma
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摘要 目的:检测白细胞介素27(IL-27)在口腔鳞状细胞癌(oral squamous cell carcinoma,OSCC)患者血清中的表达,探讨其与OSCC临床病理因素的相关性。方法:应用酶联免疫反应(enzyme-linked immunosorbent assay,ELISA)检测40例OSCC患者和20例健康体检者血清中的IL-27水平。采用SPSS10.0软件包对检测数据进行t检验。结果 :OSCC患者血清中IL-27水平显著高于对照组(P<0.05),临床Ⅲ、Ⅳ期OSCC患者血清中IL-27水平显著高于Ⅰ、Ⅱ期患者(P<0.05);有颈淋巴结转移患者,血清IL-27水平显著高于无转移者(P<0.05)。结论:血清IL-27水平与口腔鳞状细胞癌的病理分级、临床分期及颈淋巴结转移密切相关。 PURPOSE： To explore the clinical significance of serum interleukin-27 （IL-27） level in patients with oral squamous ceil carcinoma （OSCC）. METHODS： Forty patients pathologically confirmed as OSCC were included, and 20 healthy adults were used as controls. The serum IL-27 were tested with enzyme -linked immunosorbent assay（ELISA）. Statistical analysis was performed by SPSS10.0 software package and t test was used to determine the difference. RESULTS： The level of serum IL-27 in OSCC patients was significantly higher than that in the control group （P〈0.05）. The high expression of IL-27 correlated with clinical pathologic stage （P〈0.05） and cervical lymph node metastasis （P〈 0.05）. CONCLUSION： The expression of serum IL-27 correlates significantly with the clinicopathologic stages of OSCC. Supported by National Natural Science Foundation of China （81001205）.
作者 刘琪 孙祖俊
机构地区 上海市宝山区中西医结合医院检验科 上海交通大学医学院附属第九人民医院检验科
出处 《上海口腔医学》 CAS CSCD 北大核心 2013年第2期181-183,共3页 Shanghai Journal of Stomatology
基金 国家自然科学基金(81001205)~~
关键词 IL-27 口腔鳞状细胞癌 酶联免疫反应 IL-27 Oral squamous cell carcinoma ELISA
分类号 R739.8 [医药卫生—肿瘤]
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参考文献12

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同被引文献44

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上海口腔医学
2013年 第2期

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