摘要
目的:检测白细胞介素27(IL-27)在口腔鳞状细胞癌(oral squamous cell carcinoma,OSCC)患者血清中的表达,探讨其与OSCC临床病理因素的相关性。方法:应用酶联免疫反应(enzyme-linked immunosorbent assay,ELISA)检测40例OSCC患者和20例健康体检者血清中的IL-27水平。采用SPSS10.0软件包对检测数据进行t检验。结果 :OSCC患者血清中IL-27水平显著高于对照组(P<0.05),临床Ⅲ、Ⅳ期OSCC患者血清中IL-27水平显著高于Ⅰ、Ⅱ期患者(P<0.05);有颈淋巴结转移患者,血清IL-27水平显著高于无转移者(P<0.05)。结论:血清IL-27水平与口腔鳞状细胞癌的病理分级、临床分期及颈淋巴结转移密切相关。
PURPOSE: To explore the clinical significance of serum interleukin-27 (IL-27) level in patients with oral squamous ceil carcinoma (OSCC). METHODS: Forty patients pathologically confirmed as OSCC were included, and 20 healthy adults were used as controls. The serum IL-27 were tested with enzyme -linked immunosorbent assay(ELISA). Statistical analysis was performed by SPSS10.0 software package and t test was used to determine the difference. RESULTS: The level of serum IL-27 in OSCC patients was significantly higher than that in the control group (P〈0.05). The high expression of IL-27 correlated with clinical pathologic stage (P〈0.05) and cervical lymph node metastasis (P〈 0.05). CONCLUSION: The expression of serum IL-27 correlates significantly with the clinicopathologic stages of OSCC. Supported by National Natural Science Foundation of China (81001205).
出处
《上海口腔医学》
CAS
CSCD
北大核心
2013年第2期181-183,共3页
Shanghai Journal of Stomatology
基金
国家自然科学基金(81001205)~~