不同民族高尿酸血症与肿瘤坏死因子-α和白细胞介素6的关系

Relationship between tumor necrosis factor-α and interleukin-6 with hyperuricemia in ethnic Uygur, Kazak, and Han

研究新疆地区维吾尔族、哈萨克族、汉族高尿酸血症与炎症因子肿瘤坏死因子-α、白细胞介素6的关系。随机抽取维吾尔族、哈萨克族、汉族共计1 200例，检测血尿酸及血脂、血糖等相关生化指标，检测肿瘤坏死因子-α、白细胞介素6。维吾尔族、哈萨克族、汉族的血尿酸与炎症因子水平差异均具有统计学意义；维吾尔族、哈萨克族、汉族分别比较高尿酸组与对照组间炎症因子的差异，肿瘤坏死因子-α在维吾尔族两组间的比较及在汉族2组间的比较，差异均有统计学意义，在哈萨克族2组间差异没有统计学意义；白细胞介素6分别在3个民族的2组间比较差异均有统计学意义（P＜0.01）。维吾尔族肿瘤坏死因子-α、白细胞介素6与血清尿酸呈现正相关（P＜0.01），哈萨克族肿瘤坏死因子-α与血清尿酸无相关性，而白细胞介素6与血清尿酸呈负相关（P＜0.01），汉族肿瘤坏死因子-α与血清尿酸无相关性，白细胞介素6与血清尿酸呈正相关关系（P＜0.01）。维吾尔族、哈萨克族、汉族高尿酸血症与炎症因子均具有不同程度的相关性，民族间的差异为将来高尿酸血症及相关代谢性疾病的防治提供新思路。

To analyse the relationship between tumor necrosis factor（TNF）-α and interleukin-6 with hyperuricemia in ethnic Uygur, Kazak, and Han in Xinjiang province. 1 200 cases of Uygur, Han, and Kazak populations were randomly enrolled. Serum uric acid, triglyceride, total cholesterol, high density lipoprotein-cholesterol, low density lipoprotein-cholesterol, fasting plasma glucose, body weigh and height, waist circumference, and hip circumference were measured. Waist-to-hip ratio and body mass index were calculated, and TNF-α, interleukin-6 were determined. The differences between uric acid and inflammatory factors were statistically significant; The differences in TNF-α was statistically significant between high uric acid group and control group in Uygur and Han, and the differences in interleukin-6 was statistically significant between high uric acid group and control group in Uygur, Kazak, and Han（P〈0.01）. TNF-α and interleukin-6 were positively correlated with serum uric acid in Uygur, but in Kazak only interleukin-6 was negatively correlated with serum uric acid, in Han only interleukin-6 was positively correlated with serum uric acid（P〈0.01）. Hyperuricemia was associated with inflammatory factors, TNF-α, interleukin-6, but there were ethnic differences among Uygur, Kazak, and Han, thus it may provide people of new ideas for prevention and treatment of hyperuricemia and other related metabolic disorders.