吸烟与乳腺癌发病风险的相关性及其生物学机制

Analysis of the relationship between cigarette smoking and risk of breast cancer

乳腺癌是女性肿瘤疾病中最为常见的一种恶性肿瘤,其发病率和死亡率呈现逐渐上升和低龄化的趋势。近年来,吸烟与乳腺癌发病风险之间的关系得到了广泛关注。多数研究认为,吸烟能够增加乳腺癌的发病风险。且证实随烟龄越长,其罹患乳腺癌的风险增加。烟草中的致癌物质可能存在多种致乳腺癌的生物学机制。文中就吸烟与乳腺癌之间的相关性及其可能生物学机制进行综述。

Breast cancer is the most frequent malignant tumor in female, with the gradually increasing and younger morbidity and mortality rates. Recently, the relationship between cigarette smoking and risk of breast cancer receive extensive attention. The gen- eral conclusion is that cigarette smoking clearly increases the breast cancer risk, in particular when the habit starts early in life. There were many potential biological mechanisms to suspect that exposure to the carcinogens in tobacco smoke may result in breast cancer. The present review article focuses specifically on the relationship between cigarette smoking and risk of breast cancer together with re- eently pertinent literature.