慢性阻塞性肺疾病患者血浆内脏脂肪因子水平变化及其与营养状况的关系

Relationship between Changes in Plasma Visfatin Levels and Nutritional Status in Chronic Obstructive Pulmonary Disease Patients

目的探讨血浆内脏脂肪因子(visfatin)水平变化在稳定期COPD伴营养不良患者中的意义。方法测定40例稳定期COPD患者(分为COPD伴营养不良组20例,COPD不伴组20例)及20例健康体检者的血浆visfatin、肿瘤坏死因子(TNF-α)、C反应蛋白(CRP)、瘦素(LEP)及与营养状况相关的人体重指数(BMI)。Visfatin、TNF-α等指标采用酶联免疫吸附法测定。分析visfatin与TNF-α、CRP、BMI等指标之间的相关性。结果①COPD伴营养不良组血浆visfatin浓度为(19.56±4.69)ng/ml明显高于COPD不伴营养不良组(P<0.01);②40例稳定期COPD患者血浆visfatin水平与TNF-α、CRP、LEP值呈负相关(r值分别为-0.397、-0.459,P<0.05或P<0.01),与BMI水平存在正相关(r=0.407,P<0.01)。结论血浆visfatin水平可以反映稳定期COPD患者的营养状况,其水平的变化可能在稳定期COPD患者伴发营养不良的过程中起到重要作用,但其具体机制还需进一步研究。

Objective To explore the changes and implications of plasma visfatin levels in malnourished patients with chronic ob- structive pulmonary disease（COPD） at stable stage. Methods The plasma cytokine levels （Visfatin, LEP,TNF -α and CRP） and hu- man nutrition index （BMI） of 40 patients from COPD at stable stage and 20 healthy people were assayed, and the differences and correla- tion between the three groups were cempared. The levels of cytokine was determined by ELISA. Results （1）The plasma visfatin levels of malnoarished patients were higher than those of no malnourished patients with COPD at stable stage （ P 〈 0.01 ）. （2）The plasma visfatin levels in 40 patients with COPD at stable stage were negative correlative to the plasma CRP, LEP,TNF- α （r = -0. 477, -0. 407, - 0. 365, P 〈 0.05 or P 〈 0.01 ）. Conclusion Plasma visfatin levels can reflect the nutrition status of patients with chronic obstructive pulmonary disease at stable stage. Levels change of visfatin may play the key role during the process of malnourished patients with chronic obstructive pulmonary disease at stable stage.