摘要
动脉粥样硬化是一种慢性进展性病理过程,特征为大动脉壁中的脂质斑块的形成。在诸多发病机制中,肝X受体(LXR)的作用日益受到重视。LXR属核受体超家族的配体激活的转录因子,LXR及LXR的目的基因参与脂质代谢平衡以及炎性反应。越来越多的证据显示,LXR信号系统分子在避免细胞内胆固醇过载及外流、细胞内炎症应答中发挥重要作用。
Atherosclerosis is a chronic progressive disease characterized by the accumulation of lipids and fibrous elements in the large arteries. Among the various pathogenesis, the role of liver X receptors （LXR） is drawing more attention. LXR is a ligand-activated transcription factor of nucleus receptor superfam- ily, and LXR and LXR target genes are involved in lipid homeostasis and inflammatory response. Increasing evidence indicaies that LXRs play an important role in avoiding cholesterol overload and efflux, and inflam- matory response within the cells.
出处
《医学综述》
2013年第8期1355-1358,共4页
Medical Recapitulate
基金
国家自然科学基金(81160489)
广西自然科学基金(2012GXNSFAA053080)
关键词
肝X受体
动脉粥样硬化
胆固醇外流
Liver X receptor
Atherosclerosis
. Cholesterol efflux
