多巴胺及去甲肾上腺素对失血性休克代偿期的疗效对比分析

Comparative Analysis on Therapeutic Efficacy of Dopamine and Norepinephrine on Compensated Stage of Hemorrhagic Shock

目的观察不同血管活性药物对失血性休克代偿期的治疗效果。方法选取2008年3月至2012年2月在河池市第一人民医院急诊科就诊的120例失血性休克代偿期患者,按随机数字表法分为三组,每组40例。充分补液后,三组分别应用多巴胺(DA)、去甲肾上腺素(NE)和DA联合NE治疗休克,观测三组患者治疗前后心率、血压、中心静脉压(CVP)、精神状态、肢端血运和尿量。结果与用药前比较,三组血压、CVP有所上升、精神状态及肢端血运有所改善、尿量有所增加,NE组和联合组心率下降,联合组血压、CVP的提升及精神状态和肢端血运的改善明显好于其他组,比较差异有统计学意义(P<0.05)。结论 DA、NE以及两种药物联合使用均能明显改善患者血流动力学和肾功能。

Objective To observe the therapeutic efficacy of dopamine and norepinephrine on the com- pensatory stage of hemorrhagic shock. Methods 120 patients at the compensatory stage of hemorrhagic shock admitted to Department of Emergency,the First People＇s Hospital of Hechi Hospital from March 2008 to February 2012 were selected and divided into three groups randomly（ random number table） ,40 patients each group. Three groups were respectively applied with dopamine, norepinephrine and dopamine combined with norepinephrine in the treatment for shock after adequate rehydration. The heart rate, blood pressure, CVP, mental state, acral blood circulation and urine volume were observed before and after treatment. Results Compared with pretreatment, the blood pressure and CVP ascended, mental state, acral blood circulation were improved and urine volume increased in all three groups. The heart rate descended in norepinephrine group and combined treatment group. Tbe blood pressure, CVP, mental state, acral blood circulation in com- bined treatment group were improved more obviously than those in other groups, the difference had statistical significance （ P 〈 0.05 ）. Conclusion Dopamine, norepinephrine and a combination of the two drugs could obviously improve hemodynamics and renal function of patients.