摘要
目的:研究壮药扶莲解毒补虚合剂经口服途径给药的急性毒性。方法:按照中药药理实验方法,测定小鼠半数致死量Median lethal dose(LD50)和最大耐受量(MTD)。结果按5.825g生药.mL-1给小鼠灌胃,无法测定出LD50。最大耐受量(MTD)测定,小鼠最大耐受量为466 mg.kg-1。结论:动物急性毒理研究表明,壮药扶莲解毒补虚合剂口服毒性甚小,临床应用安全可靠。
Objective:To explore the acute toxicity of Zhuang medicine Fulian detoxification tonic mixture by oral administration. Methods:Determine the median lethal dose (LD50) and the maximum tolerated dose (MTD) of mouse by the traditional Chinese medicine pharmacological experimental methods. Results:Unable to determine the LD50 from mouse lavage administration by 5. 825g· mL-1. The maximum tolerated dose (MTD) of mouse is 466 mg· kg-1. Conclusion:According to the Animal acute toxicity research, the oral toxicity of Zhuang medicine Fulian detoxification tonic mixture is low, and it is safe in clinical application.
出处
《中国民族医药杂志》
2013年第4期41-42,共2页
Journal of Medicine and Pharmacy of Chinese Minorities
基金
广西壮族自治区卫生厅中医医院制剂类科课题(GZYZ-10-07)
关键词
壮药
扶莲解毒补虚合剂
口服
急性毒性
Zhuang medicine Fulian detoxifieation tonic mixture
Oral administration
Acute toxicity