摘要
目的:研究壮药扶莲解毒补虚合剂经口服途径给药的急性毒性。方法:按照中药药理实验方法,测定小鼠半数致死量Median lethal dose(LD50)和最大耐受量(MTD)。结果按5.825g生药.mL-1给小鼠灌胃,无法测定出LD50。最大耐受量(MTD)测定,小鼠最大耐受量为466 mg.kg-1。结论:动物急性毒理研究表明,壮药扶莲解毒补虚合剂口服毒性甚小,临床应用安全可靠。
Objective：To explore the acute toxicity of Zhuang medicine Fulian detoxification tonic mixture by oral administration. Methods：Determine the median lethal dose （LD50） and the maximum tolerated dose （MTD） of mouse by the traditional Chinese medicine pharmacological experimental methods. Results：Unable to determine the LD50 from mouse lavage administration by 5. 825g· mL-1. The maximum tolerated dose （MTD） of mouse is 466 mg· kg-1. Conclusion：According to the Animal acute toxicity research, the oral toxicity of Zhuang medicine Fulian detoxification tonic mixture is low, and it is safe in clinical application.
出处
《中国民族医药杂志》
2013年第4期41-42,共2页
Journal of Medicine and Pharmacy of Chinese Minorities
基金
广西壮族自治区卫生厅中医医院制剂类科课题(GZYZ-10-07)
关键词
壮药
扶莲解毒补虚合剂
口服
急性毒性
Zhuang medicine Fulian detoxifieation tonic mixture
Oral administration
Acute toxicity
