梗塞TOAST分型与血清心肌酶补体C3纤维蛋白原关系的临床研究

Clinical Study on Relationship among Infarction TOAST Typing Serum Myocardial Enzymes Complement C3 and Fibrinogen

目的:探讨急性脑梗塞TOAST各分型患者血清心肌酶、补体C3及纤维蛋白原(Fbg)的差异以及与预后的关系。方法:将我院2010年7月至2012年6月收治的155例急性脑梗塞患者进行TOAST分型,根据分型结果将患者分为五组,即大动脉粥样硬化脑梗塞组(LAA)(37例)、心源性脑栓塞组(CE)(25例)、小动脉闭塞脑梗塞组(SAO)(52例)、明确病因性脑梗塞组(OC)(8例)和不明病因性脑梗塞组(UE)(33例)。检测并比较各组患者血清心肌酶、补体C3及纤维蛋白原(Fbg)的水平。结果:大动脉粥样硬化脑梗塞(LAA)组、心源性脑栓塞组(CE)、小动脉闭塞脑梗塞组(SAO)患者血清AST、CK、CK-MB、LDH及纤维蛋白原水平显著高于明确病因性脑梗塞组(OC)和不明病因性脑梗塞组(UE)患者,差异具有统计学意义(P<0.05),而各组患者间补体C3水平无统计学差异(P>0.05)。结论:血清心肌酶及纤维蛋白原与脑梗塞TOAST分型间存在密切联系。

Objective： To observe the difference between serum myocardial enzymes, complement C3 and fibrinogen on acute cerebral infarction patients with type TOAST each branch, and the relationship with prognosis. Method： 155 patients with acute cerebral infarction treated in our hospital from July 2010 to June 2012 were given TOAST type. And the patients were divided into 5 groups according to classification result, group LAA for 37 cases, group CE for 25 cases, group SAO for 52 cases, group OC for 8 cases and group UE for 33 cases. Detecting and comparing the level of serum myocardial enzymes, complement C3 and Fi- brinogen on patients of each group. Result： The level of serum AST, CK, CK-MB, LDH and fibrinogen of group LAA, group CE and group SAO were higher than those of group OC and group UE. The difference had statistical significance （ P〈0.05 ）. However, as for the level of complement C3, there was no statistical sig nificance among each group （P〉0.05）. Conclusion：There is close relation between serum myocardial enzymes, fibrinogen and cerebral infarction TOAST typing.