胞二磷胆碱联合二磷酸果糖治疗新生儿缺氧缺血性脑病的临床观察

Clinical Observation of Compound Cholinicytidine Diphosphate Associated with Fructose Diphosphate in Treating Neonatal Hypoxic-ischemic Encephalopathy

目的:探讨胞二磷胆碱联合二磷酸果糖治疗新生儿缺氧缺血性脑病的临床疗效及安全性。方法:将80例患儿随机分为观察组和对照组各40例,均给予常规治疗,在此基础上,对照组加用胞二磷胆碱,观察组加用胞二磷胆碱和二磷酸果糖。结果:观察组患儿意识障碍、惊厥、原始反射及肌张力改善时间明显短于对照组,差异存在统计学意义(P<0.05);观察组患儿总有效率95.00%,高于对照组的70.00%,二者差异存在统计学意义;两组患儿经过治疗后,NBNA评分均改善(P<0.05),但是观察组患儿改善更显著(P<0.01)。结论:胞二磷胆碱联合二磷酸果糖治疗新生儿缺氧缺血性脑病临床效果显著,安全性高,促进患儿康复,值得临床推广应用。

Objective： To evaluate the efficacy and safty of compound cholinicytidine diphosphate asso-ciated with fructose diphosphate in treating neonatal hypoxic-ischemic encephalopathy （ HIE ）. Method： 80 cases with HIE were divided into experimental group （40 cases} and control group （40 cases} randomly. All of them were treated by the traditional therapy, and children were treated by cholinicytidine diphosphate added in control group, while those were treated by cholinicytidine diphosphate associated with fructose diphosphate added in experimental group. Result： The disturbance of consciousness, convulsion, convul- sion, muscle tonus in experimental group were improved more quickly than those in control group （ P〈0.05 ）, and total effective rate was 95% in experimental group, which was higher than that in control group{ P〈0. 05 ）, and the value of NBNA was much more improved in experimental group, and the difference between the two groups showed statistical significance （P〈0.05） . Conclusion： Cholinicytidine diphosphate associated with fructose diphosphate in treating neonatal hypoxic-ischemic encephalopathy is safe and effective. It is worthy to be recommended.