寻常型银屑病皮损处ASC和caspase-1的表达

Expressions of apoptosis-associated speck-like protein and caspase-1 in psoriasis vulgaris

目的探讨凋亡相关斑点样蛋白(apoptosis-associated speck-like protein,ASC)和半胱氨酸蛋白酶-1(caspase-1)在银屑病发病中的作用。方法采用免疫组化方法检测30例寻常型银屑病患者皮损处ASC和caspase-1的表达和分布。结果银屑病患者皮损处表皮全层强阳性表达ASC,主要分布在胞浆、胞核;正常人对照ASC主要表达于表皮中、下部,以轻、中度表达为主。银屑病患者皮损处caspase-1亦表达于表皮全层,位于胞浆,染色呈强阳性;正常人对照caspase-1表达于基底细胞和棘细胞层下部,染色强度较弱,两组比较差异均有统计学意义(t值分别为49和55,P均<0.01)。结论 ASC和caspase-1在银屑病的炎症过程中可能发挥重要作用。

Objective To study the role of apoptosis-associated speck-like protein（ASC） and caspase-1 in pathogenesis of psoriasis vulgaris.Methods Expression and distribution of ASC and caspase-1 in 30 psoriasis vulgaris patients were detected by immunohistochemistry.Results The ASC was intensely stained and expressed in cytoplasm and nuclei of psoriasis vulgaris patients and mainly expressed in middle and lower epidermis of normal persons.The caspase-1 was weakly stained and expressed in cytoplasm and full epidermis of psoriasis vulgaris patients and in basal and lower spinous cells of normal persons（t=49,55,respectively,P0.01）.Conclusion ASC and caspase-1 play a significant role in the inflammation of psoriasis vulgarpsoriasis.